7ko7: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==== | ==Structure of the native cardiac thin filament at pCa=5.8 having upper Tn in Ca2+ free state and lower Tn in Ca2+ bound state== | ||
<StructureSection load='7ko7' size='340' side='right'caption='[[7ko7]]' scene=''> | <StructureSection load='7ko7' size='340' side='right'caption='[[7ko7]], [[Resolution|resolution]] 8.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7ko7]] is a 29 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KO7 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ko7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ko7 OCA], [https://pdbe.org/7ko7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ko7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ko7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ko7 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 8.3Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ko7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ko7 OCA], [https://pdbe.org/7ko7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ko7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ko7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ko7 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/TNNC1_PIG TNNC1_PIG] Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. | |||
==See Also== | |||
*[[Actin 3D structures|Actin 3D structures]] | |||
*[[Tropomyosin 3D structures|Tropomyosin 3D structures]] | |||
*[[Troponin 3D structures|Troponin 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Sus scrofa]] | ||
[[Category: Galkin VE]] | |||
[[Category: Risi CM]] | |||
Latest revision as of 17:57, 6 March 2024
Structure of the native cardiac thin filament at pCa=5.8 having upper Tn in Ca2+ free state and lower Tn in Ca2+ bound stateStructure of the native cardiac thin filament at pCa=5.8 having upper Tn in Ca2+ free state and lower Tn in Ca2+ bound state
Structural highlights
FunctionTNNC1_PIG Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. See Also |
| ||||||||||||||||