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| == Function == | | == Function == |
| [https://www.uniprot.org/uniprot/ACTB_CHICK ACTB_CHICK] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | | [https://www.uniprot.org/uniprot/ACTB_CHICK ACTB_CHICK] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
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| == Publication Abstract from PubMed ==
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| Cofilin/ADF proteins play key roles in the dynamics of actin, one of the most abundant and highly conserved eukaryotic proteins. We used cryoelectron microscopy to generate a 9-A resolution three-dimensional reconstruction of cofilin-decorated actin filaments, the highest resolution achieved for a complex of F-actin with an actin-binding protein. We show that the cofilin-induced change in the filament twist is due to a unique conformation of the actin molecule unrelated to any previously observed state. The changes between the actin protomer in naked F-actin and in the actin-cofilin filament are greater than the conformational changes between G- and F-actin. Our results show the structural plasticity of actin, suggest that other actin-binding proteins may also induce large but different conformational changes, and show that F-actin cannot be described by a single molecular model.
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| Remodeling of actin filaments by ADF/cofilin proteins.,Galkin VE, Orlova A, Kudryashov DS, Solodukhin A, Reisler E, Schroder GF, Egelman EH Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20568-72. Epub 2011 Dec 7. PMID:22158895<ref>PMID:22158895</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 3j0s" style="background-color:#fffaf0;"></div>
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| ==See Also== | | ==See Also== |
| *[[Actin 3D structures|Actin 3D structures]] | | *[[Actin 3D structures|Actin 3D structures]] |
| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </SX> | | </SX> |