7d1x: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older edit
No edit summary
No edit summary
 
Line 1: Line 1:


==Crystal structure of 7-alpha-hydroxyl bile acid sulfotransferase (Sult2a8)==
==Crystal structure of 7-alpha-hydroxyl bile acid sulfotransferase (Sult2a8)==
<StructureSection load='7d1x' size='340' side='right'caption='[[7d1x]]' scene=''>
<StructureSection load='7d1x' size='340' side='right'caption='[[7d1x]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D1X FirstGlance]. <br>
<table><tr><td colspan='2'>[[7d1x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D1X FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d1x OCA], [https://pdbe.org/7d1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d1x RCSB], [https://www.ebi.ac.uk/pdbsum/7d1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d1x ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A3P:ADENOSINE-3-5-DIPHOSPHATE'>A3P</scene>, <scene name='pdbligand=CHD:CHOLIC+ACID'>CHD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d1x OCA], [https://pdbe.org/7d1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d1x RCSB], [https://www.ebi.ac.uk/pdbsum/7d1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d1x ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ST2A8_MOUSE ST2A8_MOUSE] Hepatic sulfotransferase involved in the maintenance of bile acid homeostasis and energy balance. Catalyzes the transfer of sulfonate group from 3'-phosphoadenylyl sulfate (PAPS) to the 7-alpha hydroxy group of primary bile acids to form 7-monosulfate derivatives in the pathway of bile acid elimination. Displays high catalytic efficiency toward cholate, chenodeoxycholate and their glycine and taurine conjugates.<ref>PMID:28442498</ref> <ref>PMID:29685090</ref> <ref>PMID:33872606</ref>
==See Also==
*[[Sulfotransferase 3D structures|Sulfotransferase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Au WNS]]
[[Category: Au WNS]]
[[Category: Wang K]]
[[Category: Wang K]]

Latest revision as of 19:23, 29 November 2023

Crystal structure of 7-alpha-hydroxyl bile acid sulfotransferase (Sult2a8)Crystal structure of 7-alpha-hydroxyl bile acid sulfotransferase (Sult2a8)

Structural highlights

7d1x is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.5Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ST2A8_MOUSE Hepatic sulfotransferase involved in the maintenance of bile acid homeostasis and energy balance. Catalyzes the transfer of sulfonate group from 3'-phosphoadenylyl sulfate (PAPS) to the 7-alpha hydroxy group of primary bile acids to form 7-monosulfate derivatives in the pathway of bile acid elimination. Displays high catalytic efficiency toward cholate, chenodeoxycholate and their glycine and taurine conjugates.[1] [2] [3]

See Also

References

  1. ↑ Feng L, Yuen YL, Xu J, Liu X, Chan MY, Wang K, Fong WP, Cheung WT, Lee SS. Identification and characterization of a novel PPARα-regulated and 7α-hydroxyl bile acid-preferring cytosolic sulfotransferase mL-STL (Sult2a8). J Lipid Res. 2017 Jun;58(6):1114-1131. PMID:28442498 doi:10.1194/jlr.M074302
  2. ↑ Shimohira T, Kurogi K, Liu MC, Suiko M, Sakakibara Y. The critical role of His48 in mouse cytosolic sulfotransferase SULT2A8 for the 7α-hydroxyl sulfation of bile acids. Biosci Biotechnol Biochem. 2018 Aug;82(8):1359-1365. PMID:29685090 doi:10.1080/09168451.2018.1464897
  3. ↑ Wang K, Chan YC, So PK, Liu X, Feng L, Cheung WT, Lee SS, Au SW. Structure of mouse cytosolic sulfotransferase SULT2A8 provides insight into sulfonation of 7α-hydroxyl bile acids. J Lipid Res. 2021;62:100074. PMID:33872606 doi:10.1016/j.jlr.2021.100074

7d1x, resolution 2.50Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=7d1x&oldid=3968818"