7d1x

Crystal structure of 7-alpha-hydroxyl bile acid sulfotransferase (Sult2a8)Crystal structure of 7-alpha-hydroxyl bile acid sulfotransferase (Sult2a8)

Structural highlights

7d1x is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.5Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ST2A8_MOUSE Hepatic sulfotransferase involved in the maintenance of bile acid homeostasis and energy balance. Catalyzes the transfer of sulfonate group from 3'-phosphoadenylyl sulfate (PAPS) to the 7-alpha hydroxy group of primary bile acids to form 7-monosulfate derivatives in the pathway of bile acid elimination. Displays high catalytic efficiency toward cholate, chenodeoxycholate and their glycine and taurine conjugates.^[1] ^[2] ^[3]

References

↑ Feng L, Yuen YL, Xu J, Liu X, Chan MY, Wang K, Fong WP, Cheung WT, Lee SS. Identification and characterization of a novel PPARα-regulated and 7α-hydroxyl bile acid-preferring cytosolic sulfotransferase mL-STL (Sult2a8). J Lipid Res. 2017 Jun;58(6):1114-1131. PMID:28442498 doi:10.1194/jlr.M074302
↑ Shimohira T, Kurogi K, Liu MC, Suiko M, Sakakibara Y. The critical role of His48 in mouse cytosolic sulfotransferase SULT2A8 for the 7α-hydroxyl sulfation of bile acids. Biosci Biotechnol Biochem. 2018 Aug;82(8):1359-1365. PMID:29685090 doi:10.1080/09168451.2018.1464897
↑ Wang K, Chan YC, So PK, Liu X, Feng L, Cheung WT, Lee SS, Au SW. Structure of mouse cytosolic sulfotransferase SULT2A8 provides insight into sulfonation of 7α-hydroxyl bile acids. J Lipid Res. 2021;62:100074. PMID:33872606 doi:10.1016/j.jlr.2021.100074

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OCA

[1] Feng L, Yuen YL, Xu J, Liu X, Chan MY, Wang K, Fong WP, Cheung WT, Lee SS. Identification and characterization of a novel PPARα-regulated and 7α-hydroxyl bile acid-preferring cytosolic sulfotransferase mL-STL (Sult2a8). J Lipid Res. 2017 Jun;58(6):1114-1131. PMID:28442498 doi:10.1194/jlr.M074302

[2] Shimohira T, Kurogi K, Liu MC, Suiko M, Sakakibara Y. The critical role of His48 in mouse cytosolic sulfotransferase SULT2A8 for the 7α-hydroxyl sulfation of bile acids. Biosci Biotechnol Biochem. 2018 Aug;82(8):1359-1365. PMID:29685090 doi:10.1080/09168451.2018.1464897

[3] Wang K, Chan YC, So PK, Liu X, Feng L, Cheung WT, Lee SS, Au SW. Structure of mouse cytosolic sulfotransferase SULT2A8 provides insight into sulfonation of 7α-hydroxyl bile acids. J Lipid Res. 2021;62:100074. PMID:33872606 doi:10.1016/j.jlr.2021.100074

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