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==Restructuring hemagglutinin-neuraminidase (HN) of Newcastle disease virus produced from Oryza sativa== | ==Restructuring hemagglutinin-neuraminidase (HN) of Newcastle disease virus produced from Oryza sativa== | ||
<StructureSection load='7bwu' size='340' side='right'caption='[[7bwu]]' scene=''> | <StructureSection load='7bwu' size='340' side='right'caption='[[7bwu]], [[Resolution|resolution]] 1.87Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BWU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BWU FirstGlance]. <br> | <table><tr><td colspan='2'>[[7bwu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Avian_orthoavulavirus_1 Avian orthoavulavirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BWU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BWU FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bwu OCA], [https://pdbe.org/7bwu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bwu RCSB], [https://www.ebi.ac.uk/pdbsum/7bwu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bwu ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bwu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bwu OCA], [https://pdbe.org/7bwu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bwu RCSB], [https://www.ebi.ac.uk/pdbsum/7bwu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bwu ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/I7EFR1_9MONO I7EFR1_9MONO] Mediates the viral entry into the host cell together with fusion/F protein. Attaches the virus to sialic acid-containing cell receptors and thereby initiates infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion.[ARBA:ARBA00003736] Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.[ARBA:ARBA00003028] | |||
==See Also== | |||
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Avian orthoavulavirus 1]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ma FS]] | [[Category: Ma FS]] | ||
[[Category: Zhang GP]] | [[Category: Zhang GP]] | ||
Revision as of 18:38, 29 November 2023
Restructuring hemagglutinin-neuraminidase (HN) of Newcastle disease virus produced from Oryza sativaRestructuring hemagglutinin-neuraminidase (HN) of Newcastle disease virus produced from Oryza sativa
Structural highlights
FunctionI7EFR1_9MONO Mediates the viral entry into the host cell together with fusion/F protein. Attaches the virus to sialic acid-containing cell receptors and thereby initiates infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion.[ARBA:ARBA00003736] Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.[ARBA:ARBA00003028] See Also |
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