6l90: Difference between revisions

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<StructureSection load='6l90' size='340' side='right'caption='[[6l90]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
<StructureSection load='6l90' size='340' side='right'caption='[[6l90]], [[Resolution|resolution]] 2.02&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6l90]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L90 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6L90 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6l90]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Siraitia_grosvenorii Siraitia grosvenorii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L90 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.02&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6l90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l90 OCA], [http://pdbe.org/6l90 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6l90 RCSB], [http://www.ebi.ac.uk/pdbsum/6l90 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6l90 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l90 OCA], [https://pdbe.org/6l90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l90 RCSB], [https://www.ebi.ac.uk/pdbsum/6l90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l90 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/74AC1_SIRGR 74AC1_SIRGR] Catalyzes the transfer of a glucose moiety to the C-3 hydroxyl of mogrol to form mogroside IE (PubMed:25759326, Ref.3). Besides mogrol, UGT74AC1 also shows activity in vitro with quercetin and naringenin as substrate (PubMed:25759326).<ref>PMID:25759326</ref> <ref>PMID:25759326</ref>
==See Also==
*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Li, J]]
[[Category: Siraitia grosvenorii]]
[[Category: Liu, W D]]
[[Category: Li J]]
[[Category: Shan, N]]
[[Category: Liu WD]]
[[Category: Sun, Y X]]
[[Category: Shan N]]
[[Category: Yang, J G]]
[[Category: Sun YX]]
[[Category: Transferase]]
[[Category: Yang JG]]

Latest revision as of 13:53, 22 November 2023

Crystal structure of ugt transferase enzymeCrystal structure of ugt transferase enzyme

Structural highlights

6l90 is a 1 chain structure with sequence from Siraitia grosvenorii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.02Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

74AC1_SIRGR Catalyzes the transfer of a glucose moiety to the C-3 hydroxyl of mogrol to form mogroside IE (PubMed:25759326, Ref.3). Besides mogrol, UGT74AC1 also shows activity in vitro with quercetin and naringenin as substrate (PubMed:25759326).[1] [2]

See Also

References

  1. ↑ Dai L, Liu C, Zhu Y, Zhang J, Men Y, Zeng Y, Sun Y. Functional Characterization of Cucurbitadienol Synthase and Triterpene Glycosyltransferase Involved in Biosynthesis of Mogrosides from Siraitia grosvenorii. Plant Cell Physiol. 2015 Jun;56(6):1172-82. PMID:25759326 doi:10.1093/pcp/pcv043
  2. ↑ Dai L, Liu C, Zhu Y, Zhang J, Men Y, Zeng Y, Sun Y. Functional Characterization of Cucurbitadienol Synthase and Triterpene Glycosyltransferase Involved in Biosynthesis of Mogrosides from Siraitia grosvenorii. Plant Cell Physiol. 2015 Jun;56(6):1172-82. PMID:25759326 doi:10.1093/pcp/pcv043

6l90, resolution 2.02Å

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