8ayf: Difference between revisions

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'''Unreleased structure'''


The entry 8ayf is ON HOLD  until Paper Publication
==Crystal structure of human Sphingosine-1-phosphate lyase 1==
 
<StructureSection load='8ayf' size='340' side='right'caption='[[8ayf]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8ayf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AYF FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ayf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ayf OCA], [https://pdbe.org/8ayf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ayf RCSB], [https://www.ebi.ac.uk/pdbsum/8ayf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ayf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SGPL1_HUMAN SGPL1_HUMAN] Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.<ref>PMID:14570870</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Catalano F]]
[[Category: Cellini B]]
[[Category: Giardina G]]
[[Category: Pampalone G]]

Latest revision as of 14:24, 15 November 2023

Crystal structure of human Sphingosine-1-phosphate lyase 1Crystal structure of human Sphingosine-1-phosphate lyase 1

Structural highlights

8ayf is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.84Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SGPL1_HUMAN Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.[1]

References

  1. ↑ Reiss U, Oskouian B, Zhou J, Gupta V, Sooriyakumaran P, Kelly S, Wang E, Merrill AH Jr, Saba JD. Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. J Biol Chem. 2004 Jan 9;279(2):1281-90. Epub 2003 Oct 21. PMID:14570870 doi:http://dx.doi.org/10.1074/jbc.M309646200

8ayf, resolution 1.84Å

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OCA
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