8ayf

Crystal structure of human Sphingosine-1-phosphate lyase 1Crystal structure of human Sphingosine-1-phosphate lyase 1

Structural highlights

8ayf is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.84Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SGPL1_HUMAN Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.^[1]

References

↑ Reiss U, Oskouian B, Zhou J, Gupta V, Sooriyakumaran P, Kelly S, Wang E, Merrill AH Jr, Saba JD. Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. J Biol Chem. 2004 Jan 9;279(2):1281-90. Epub 2003 Oct 21. PMID:14570870 doi:http://dx.doi.org/10.1074/jbc.M309646200

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OCA

[1] Reiss U, Oskouian B, Zhou J, Gupta V, Sooriyakumaran P, Kelly S, Wang E, Merrill AH Jr, Saba JD. Sphingosine-phosphate lyase enhances stress-induced ceramide generation and apoptosis. J Biol Chem. 2004 Jan 9;279(2):1281-90. Epub 2003 Oct 21. PMID:14570870 doi:http://dx.doi.org/10.1074/jbc.M309646200

[1]

8ayf

Crystal structure of human Sphingosine-1-phosphate lyase 1Crystal structure of human Sphingosine-1-phosphate lyase 1

Structural highlights

Function

References

Contents

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8ayf

Crystal structure of human Sphingosine-1-phosphate lyase 1Crystal structure of human Sphingosine-1-phosphate lyase 1

Structural highlights

Function

References

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