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==Crystal structure of a peptide chain release factor 3 (prfC) from Stenotrophomonas maltophilia bound to GDP== | ==Crystal structure of a peptide chain release factor 3 (prfC) from Stenotrophomonas maltophilia bound to GDP== | ||
<StructureSection load='7siq' size='340' side='right'caption='[[7siq]]' scene=''> | <StructureSection load='7siq' size='340' side='right'caption='[[7siq]], [[Resolution|resolution]] 2.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SIQ FirstGlance]. <br> | <table><tr><td colspan='2'>[[7siq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Stenotrophomonas_maltophilia_K279a Stenotrophomonas maltophilia K279a]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SIQ FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7siq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7siq OCA], [https://pdbe.org/7siq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7siq RCSB], [https://www.ebi.ac.uk/pdbsum/7siq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7siq ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7siq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7siq OCA], [https://pdbe.org/7siq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7siq RCSB], [https://www.ebi.ac.uk/pdbsum/7siq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7siq ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/RF3_STRMK RF3_STRMK] Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.[HAMAP-Rule:MF_00072] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Stenotrophomonas maltophilia K279a]] | |||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
Latest revision as of 19:51, 18 October 2023
Crystal structure of a peptide chain release factor 3 (prfC) from Stenotrophomonas maltophilia bound to GDPCrystal structure of a peptide chain release factor 3 (prfC) from Stenotrophomonas maltophilia bound to GDP
Structural highlights
FunctionRF3_STRMK Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.[HAMAP-Rule:MF_00072] |
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