3atz: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
<StructureSection load='3atz' size='340' side='right'caption='[[3atz]], [[Resolution|resolution]] 2.04Å' scene=''> | <StructureSection load='3atz' size='340' side='right'caption='[[3atz]], [[Resolution|resolution]] 2.04Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3atz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3atz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ATZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ATZ FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=HBA:P-HYDROXYBENZALDEHYDE'>HBA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3atz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3atz OCA], [https://pdbe.org/3atz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3atz RCSB], [https://www.ebi.ac.uk/pdbsum/3atz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3atz ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3atz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3atz OCA], [https://pdbe.org/3atz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3atz RCSB], [https://www.ebi.ac.uk/pdbsum/3atz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3atz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q8I6L9_TRYCR Q8I6L9_TRYCR] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 26: | Line 27: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Trypanosoma cruzi]] | ||
[[Category: Inaka | [[Category: Inaka K]] | ||
[[Category: Inoue | [[Category: Inoue T]] | ||
[[Category: Matsumura | [[Category: Matsumura H]] | ||
[[Category: Mizohata | [[Category: Mizohata E]] | ||
[[Category: Okamoto | [[Category: Okamoto N]] | ||
[[Category: Sugiyama | [[Category: Sugiyama S]] | ||
[[Category: Tokuoka | [[Category: Tokuoka K]] | ||
[[Category: Uchiyama | [[Category: Uchiyama N]] | ||
[[Category: Urade | [[Category: Urade Y]] | ||
[[Category: Yamaguchi | [[Category: Yamaguchi K]] | ||
Revision as of 18:55, 4 October 2023
Crystal structure of TcOYE with pHBACrystal structure of TcOYE with pHBA
Structural highlights
FunctionPublication Abstract from PubMedOld yellow enzyme (OYE) is an NADPH oxidoreductase capable of reducing a variety of compounds. It contains flavin mononucleotide (FMN) as a prosthetic group. A ternary complex structure of OYE from Trypanosoma cruzi (TcOYE) with FMN and one of the substrates, p-hydroxybenzaldehyde, shows a striking movement around the active site upon binding of the substrate. From a structural comparison of other OYE complexed with 12-oxophytodienoate, we have constructed a complex structure with another substrate, prostaglandin H(2) (PGH(2)), to provide a proposed stereoselective reaction mechanism for the reduction of PGH(2) to prostaglandin F(2alpha) by TcOYE. Structural insight into the stereoselective production of PGF2alpha by Old Yellow Enzyme from Trypanosoma cruzi.,Okamoto N, Yamaguchi K, Mizohata E, Tokuoka K, Uchiyama N, Sugiyama S, Matsumura H, Inaka K, Urade Y, Inoue T J Biochem. 2011 Nov;150(5):563-8. doi: 10.1093/jb/mvr096. Epub 2011 Aug, 12. PMID:21840922[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
|
| ||||||||||||||||||