6ap0: Difference between revisions

<table><tr><td colspan='2'>[[6ap0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AP0 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.581&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ap0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ap0 OCA], [https://pdbe.org/6ap0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ap0 RCSB], [https://www.ebi.ac.uk/pdbsum/6ap0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ap0 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/C8AP2_HUMAN C8AP2_HUMAN] Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.<ref>PMID:12477726</ref> <ref>PMID:15698540</ref> <ref>PMID:17003125</ref> <ref>PMID:17245429</ref>  

[[Category: Aik WS]]

[[Category: Tong L]]