4l7g: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4l7g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L7G FirstGlance]. <br> | <table><tr><td colspan='2'>[[4l7g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L7G FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1W0:(3AS,7AR)-7A-[3-(PYRIMIDIN-5-YL)PHENYL]-3A,6,7,7A-TETRAHYDRO-4H-PYRANO[4,3-D][1,3]OXAZOL-2-AMINE'>1W0</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.38Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1W0:(3AS,7AR)-7A-[3-(PYRIMIDIN-5-YL)PHENYL]-3A,6,7,7A-TETRAHYDRO-4H-PYRANO[4,3-D][1,3]OXAZOL-2-AMINE'>1W0</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7g OCA], [https://pdbe.org/4l7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l7g RCSB], [https://www.ebi.ac.uk/pdbsum/4l7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l7g ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l7g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7g OCA], [https://pdbe.org/4l7g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l7g RCSB], [https://www.ebi.ac.uk/pdbsum/4l7g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l7g ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Latest revision as of 19:13, 20 September 2023
Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE1)Diethylaminosulfur Trifluoride-Mediated Intramolecular Cyclization of 2-hydroxy-benzylureas to Fused Bicyclic Aminooxazoline Compounds and Evaluation of Their Biochemical Activity Against Beta-Secretase-1 (BACE1)
Structural highlights
FunctionBACE1_HUMAN Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.[1] [2] See AlsoReferences
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