4iar: Difference between revisions

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<StructureSection load='4iar' size='340' side='right'caption='[[4iar]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='4iar' size='340' side='right'caption='[[4iar]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4iar]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. The August 2013 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serotonin Receptor''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2013_8 10.2210/rcsb_pdb/mom_2013_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IAR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IAR FirstGlance]. <br>
<table><tr><td colspan='2'>[[4iar]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. The August 2013 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Serotonin Receptor''  by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2013_8 10.2210/rcsb_pdb/mom_2013_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IAR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IAR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ERM:ERGOTAMINE'>ERM</scene>, <scene name='pdbligand=OLB:(2S)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLB</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4iaq|4iaq]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ERM:ERGOTAMINE'>ERM</scene>, <scene name='pdbligand=OLB:(2S)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLB</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HTR1B, HTR1DB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iar OCA], [https://pdbe.org/4iar PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iar RCSB], [https://www.ebi.ac.uk/pdbsum/4iar PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iar ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iar OCA], [https://pdbe.org/4iar PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iar RCSB], [https://www.ebi.ac.uk/pdbsum/4iar PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iar ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/5HT1B_HUMAN 5HT1B_HUMAN]] This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.  
[https://www.uniprot.org/uniprot/C562_ECOLX C562_ECOLX] Electron-transport protein of unknown function.[https://www.uniprot.org/uniprot/5HT1B_HUMAN 5HT1B_HUMAN] This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Serotonin Receptor]]
[[Category: Serotonin Receptor]]
[[Category: Bai, F]]
[[Category: Bai F]]
[[Category: Cherezov, V]]
[[Category: Cherezov V]]
[[Category: GPCR, GPCR Network]]
[[Category: Gao X]]
[[Category: Gao, X]]
[[Category: Han GW]]
[[Category: Han, G W]]
[[Category: Huang X]]
[[Category: Huang, X]]
[[Category: Jiang H]]
[[Category: Jiang, H]]
[[Category: Jiang Y]]
[[Category: Jiang, Y]]
[[Category: Katritch V]]
[[Category: Katritch, V]]
[[Category: Liu W]]
[[Category: Liu, W]]
[[Category: Ma J]]
[[Category: Ma, J]]
[[Category: McCorvy JD]]
[[Category: McCorvy, J D]]
[[Category: Melcher K]]
[[Category: Melcher, K]]
[[Category: Roth BL]]
[[Category: Roth, B L]]
[[Category: Stevens RC]]
[[Category: Stevens, R C]]
[[Category: Vardy E]]
[[Category: Vardy, E]]
[[Category: Wacker D]]
[[Category: Wacker, D]]
[[Category: Wang C]]
[[Category: Wang, C]]
[[Category: Wu H]]
[[Category: Wu, H]]
[[Category: Xu HE]]
[[Category: Xu, H E]]
[[Category: Yang H]]
[[Category: Yang, H]]
[[Category: Yang L]]
[[Category: Yang, L]]
[[Category: Zhang C]]
[[Category: Zhang, C]]
[[Category: Zhou EX]]
[[Category: Zhou, E X]]
[[Category: Electron transport]]
[[Category: Ergotamine]]
[[Category: Gpcr]]
[[Category: Gpcr dock]]
[[Category: Gpcr network]]
[[Category: Membrane protein]]
[[Category: Novel protein engineering]]
[[Category: Psi-biology]]
[[Category: Signaling protein]]
[[Category: Structural genomic]]

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