1s1g: Difference between revisions

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<StructureSection load='1s1g' size='340' side='right'caption='[[1s1g]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='1s1g' size='340' side='right'caption='[[1s1g]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1s1g]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1G OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1S1G FirstGlance]. <br>
<table><tr><td colspan='2'>[[1s1g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1S1G FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1s1e|1s1e]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KCND3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1s1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1g OCA], [https://pdbe.org/1s1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1s1g RCSB], [https://www.ebi.ac.uk/pdbsum/1s1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1s1g ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1s1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1s1g OCA], [http://pdbe.org/1s1g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1s1g RCSB], [http://www.ebi.ac.uk/pdbsum/1s1g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1s1g ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/KCND3_HUMAN KCND3_HUMAN]] Note=KCND3 rare variants may confer risk for lethal ventricular arrhytmias and be associated with autopsy-negative sudden unexplained death syndrome (SUDS).<ref>PMID:22457051</ref>
[https://www.uniprot.org/uniprot/KCND3_HUMAN KCND3_HUMAN] Note=KCND3 rare variants may confer risk for lethal ventricular arrhytmias and be associated with autopsy-negative sudden unexplained death syndrome (SUDS).<ref>PMID:22457051</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/KCND3_HUMAN KCND3_HUMAN]] Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.<ref>PMID:9843794</ref> <ref>PMID:10200233</ref>
[https://www.uniprot.org/uniprot/KCND3_HUMAN KCND3_HUMAN] Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.<ref>PMID:9843794</ref> <ref>PMID:10200233</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bowlby, M R]]
[[Category: Bowlby MR]]
[[Category: Carroll, K C]]
[[Category: Carroll KC]]
[[Category: Chanda, P]]
[[Category: Chanda P]]
[[Category: Edris, W]]
[[Category: Edris W]]
[[Category: Jow, F]]
[[Category: Jow F]]
[[Category: Katz, A H]]
[[Category: Katz AH]]
[[Category: Kopsco, D C]]
[[Category: Kopsco DC]]
[[Category: Lin, L]]
[[Category: Lin L]]
[[Category: Lu, Q]]
[[Category: Lu Q]]
[[Category: Malakian, K]]
[[Category: Malakian K]]
[[Category: Megules, J]]
[[Category: Megules J]]
[[Category: Mosyak, L]]
[[Category: Mosyak L]]
[[Category: Olland, S]]
[[Category: Olland S]]
[[Category: Rhodes, K J]]
[[Category: Rhodes KJ]]
[[Category: Scannevin, R H]]
[[Category: Scannevin RH]]
[[Category: Somers, W]]
[[Category: Somers W]]
[[Category: Stahl, M]]
[[Category: Stahl M]]
[[Category: Taylor, M]]
[[Category: Taylor M]]
[[Category: Wang, K W]]
[[Category: Wang KW]]
[[Category: Xu, W X]]
[[Category: Xu WX]]
[[Category: Xu, Z B]]
[[Category: Xu ZB]]
[[Category: K+ channel]]
[[Category: T1 domain]]
[[Category: Tetramerization domain]]
[[Category: Transport protein]]

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