1m42: Difference between revisions

Revision as of 00:36, 3 May 2008

Solution structure of apoCopC from Pseudomonas syringae

OverviewOverview

The structure of the metal-free form of CopC, a protein involved in copper homeostasis, has been obtained. The fold is a Greek key beta barrel similar to that of functionally unrelated blue copper proteins but with important structural variations. The protein binds one equivalent of copper (II) with relatively high affinity and contains a cluster of conserved residues (His1, Glu27, Asp89, and His91) which could form a water-accessible metal binding site. The structure also reveals a loop containing the M(X)(n)M motif which is present in a number of proteins also involved in copper homeostasis. The present structure represents a link between copper-trafficking proteins and cupredoxins. Within a structural and genomic analysis, the role of CopC in copper trafficking is discussed.

About this StructureAbout this Structure

1M42 is a Single protein structure of sequence from Pseudomonas syringae. Full crystallographic information is available from OCA.

ReferenceReference

Solution structure of CopC: a cupredoxin-like protein involved in copper homeostasis., Arnesano F, Banci L, Bertini I, Thompsett AR, Structure. 2002 Oct;10(10):1337-47. PMID:12377120 Page seeded by OCA on Sat May 3 00:36:07 2008

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OCA

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 [[Image:1m42.gif|left|200px]]
- {{Structure
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-|GENE= COPC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=317 Pseudomonas syringae])
+-->
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-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1m42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m42 OCA], [http://www.ebi.ac.uk/pdbsum/1m42 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1m42 RCSB]</span>
-}}
 '''Solution structure of apoCopC from Pseudomonas syringae'''
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 [[Category: Bertini, I.]]
 [[Category: Thompsett, A R.]]
-[[Category: copper trafficking]]
+[[Category: Copper trafficking]]
-[[Category: cupredoxin]]
+[[Category: Cupredoxin]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 00:36:07 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:10:55 2008''