7y5o: Difference between revisions

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'''Unreleased structure'''


The entry 7y5o is ON HOLD  until 2024-12-27
==Crystal structure of human CAF-1 core complex in spacegroup P21==
 
<StructureSection load='7y5o' size='340' side='right'caption='[[7y5o]], [[Resolution|resolution]] 3.57&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7y5o]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y5O FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.57&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y5o OCA], [https://pdbe.org/7y5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y5o RCSB], [https://www.ebi.ac.uk/pdbsum/7y5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y5o ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAF1B_HUMAN CAF1B_HUMAN] Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.<ref>PMID:9813080</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Liu CP]]
[[Category: Wang MZ]]
[[Category: Xu RM]]

Latest revision as of 11:16, 16 August 2023

Crystal structure of human CAF-1 core complex in spacegroup P21Crystal structure of human CAF-1 core complex in spacegroup P21

Structural highlights

7y5o is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.57Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CAF1B_HUMAN Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.[1]

References

  1. ↑ Martini E, Roche DM, Marheineke K, Verreault A, Almouzni G. Recruitment of phosphorylated chromatin assembly factor 1 to chromatin after UV irradiation of human cells. J Cell Biol. 1998 Nov 2;143(3):563-75. PMID:9813080 doi:10.1083/jcb.143.3.563

7y5o, resolution 3.57Å

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