7y5o

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Crystal structure of human CAF-1 core complex in spacegroup P21Crystal structure of human CAF-1 core complex in spacegroup P21

Structural highlights

7y5o is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.57Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CAF1B_HUMAN Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer.[1]

References

  1. ↑ Martini E, Roche DM, Marheineke K, Verreault A, Almouzni G. Recruitment of phosphorylated chromatin assembly factor 1 to chromatin after UV irradiation of human cells. J Cell Biol. 1998 Nov 2;143(3):563-75. PMID:9813080 doi:10.1083/jcb.143.3.563

7y5o, resolution 3.57Å

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OCA
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