8bpf: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[8bpf]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BPF FirstGlance]. <br> | <table><tr><td colspan='2'>[[8bpf]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BPF FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bpf OCA], [https://pdbe.org/8bpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bpf RCSB], [https://www.ebi.ac.uk/pdbsum/8bpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bpf ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bpf OCA], [https://pdbe.org/8bpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bpf RCSB], [https://www.ebi.ac.uk/pdbsum/8bpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bpf ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Latest revision as of 15:51, 26 July 2023
FcMR binding at subunit Fcu1 of IgM pentamerFcMR binding at subunit Fcu1 of IgM pentamer
Structural highlights
FunctionFAIM3_HUMAN May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.[1] References |
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