8bpf

FcMR binding at subunit Fcu1 of IgM pentamerFcMR binding at subunit Fcu1 of IgM pentamer

Structural highlights

8bpf is a 12 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.5Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FAIM3_HUMAN May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.^[1]

References

↑ Hitoshi Y, Lorens J, Kitada SI, Fisher J, LaBarge M, Ring HZ, Francke U, Reed JC, Kinoshita S, Nolan GP. Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. Immunity. 1998 Apr;8(4):461-71. PMID:9586636

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OCA

[1] Hitoshi Y, Lorens J, Kitada SI, Fisher J, LaBarge M, Ring HZ, Francke U, Reed JC, Kinoshita S, Nolan GP. Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells. Immunity. 1998 Apr;8(4):461-71. PMID:9586636

[1]

8bpf

FcMR binding at subunit Fcu1 of IgM pentamerFcMR binding at subunit Fcu1 of IgM pentamer

Structural highlights

Function

References

Contents

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8bpf

FcMR binding at subunit Fcu1 of IgM pentamerFcMR binding at subunit Fcu1 of IgM pentamer

Structural highlights

Function

References

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