5w3g: Difference between revisions

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==Solution Structure of ETS Transcription Factor PU.1==
==Solution Structure of ETS Transcription Factor PU.1==
<StructureSection load='5w3g' size='340' side='right'caption='[[5w3g]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='5w3g' size='340' side='right'caption='[[5w3g]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5w3g]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W3G OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5W3G FirstGlance]. <br>
<table><tr><td colspan='2'>[[5w3g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W3G FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5w3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w3g OCA], [http://pdbe.org/5w3g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w3g RCSB], [http://www.ebi.ac.uk/pdbsum/5w3g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w3g ProSAT]</span></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w3g OCA], [https://pdbe.org/5w3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w3g RCSB], [https://www.ebi.ac.uk/pdbsum/5w3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w3g ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/SPI1_MOUSE SPI1_MOUSE]] Note=Involved in murine acute Friend erythroleukemia. It is a target region for SFFV proviral insertion.  
[https://www.uniprot.org/uniprot/SPI1_MOUSE SPI1_MOUSE] Note=Involved in murine acute Friend erythroleukemia. It is a target region for SFFV proviral insertion.
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SPI1_MOUSE SPI1_MOUSE]] Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.<ref>PMID:8626664</ref>
[https://www.uniprot.org/uniprot/SPI1_MOUSE SPI1_MOUSE] Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.<ref>PMID:8626664</ref>  
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lau, D K.W]]
[[Category: Mus musculus]]
[[Category: McIntosh, L P]]
[[Category: Lau DKW]]
[[Category: Okon, M]]
[[Category: McIntosh LP]]
[[Category: Dna binding protein]]
[[Category: Okon M]]
[[Category: Winged helix-turn-helix]]

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