5w3g

Solution Structure of ETS Transcription Factor PU.1Solution Structure of ETS Transcription Factor PU.1

Structural highlights

5w3g is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

SPI1_MOUSE Note=Involved in murine acute Friend erythroleukemia. It is a target region for SFFV proviral insertion.

Function

SPI1_MOUSE Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.^[1]

References

↑ Hallier M, Tavitian A, Moreau-Gachelin F. The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb. J Biol Chem. 1996 May 10;271(19):11177-81. PMID:8626664

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OCA

[1] Hallier M, Tavitian A, Moreau-Gachelin F. The transcription factor Spi-1/PU.1 binds RNA and interferes with the RNA-binding protein p54nrb. J Biol Chem. 1996 May 10;271(19):11177-81. PMID:8626664

[1]

5w3g

Solution Structure of ETS Transcription Factor PU.1Solution Structure of ETS Transcription Factor PU.1

Structural highlights

Disease

Function

References

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5w3g

Solution Structure of ETS Transcription Factor PU.1Solution Structure of ETS Transcription Factor PU.1

Structural highlights

Disease

Function

References

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