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==CryoEM structure of miniGo-coupled hM4Di in complex with DCZ== | |||
<StructureSection load='8e9x' size='340' side='right'caption='[[8e9x]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8e9x]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E9X FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WEC:11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine'>WEC</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e9x OCA], [https://pdbe.org/8e9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e9x RCSB], [https://www.ebi.ac.uk/pdbsum/8e9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e9x ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ACM4_HUMAN ACM4_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Fay JF]] | |||
[[Category: Roth BL]] | |||
[[Category: Zhang S]] | |||
Latest revision as of 13:46, 30 November 2022
CryoEM structure of miniGo-coupled hM4Di in complex with DCZCryoEM structure of miniGo-coupled hM4Di in complex with DCZ
Structural highlights
FunctionACM4_HUMAN The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. |
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