8e9x

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CryoEM structure of miniGo-coupled hM4Di in complex with DCZCryoEM structure of miniGo-coupled hM4Di in complex with DCZ

Structural highlights

8e9x is a 5 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ACM4_HUMAN The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.

8e9x, resolution 2.70Å

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OCA