4j1o: Difference between revisions

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<StructureSection load='4j1o' size='340' side='right'caption='[[4j1o]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
<StructureSection load='4j1o' size='340' side='right'caption='[[4j1o]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4j1o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pardp Pardp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J1O FirstGlance]. <br>
<table><tr><td colspan='2'>[[4j1o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Paracoccus_denitrificans_PD1222 Paracoccus denitrificans PD1222]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4J1O FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PBE:1,1-DIMETHYL-PROLINIUM'>PBE</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PBE:1,1-DIMETHYL-PROLINIUM'>PBE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1o OCA], [http://pdbe.org/4j1o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j1o RCSB], [http://www.ebi.ac.uk/pdbsum/4j1o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j1o ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4j1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j1o OCA], [https://pdbe.org/4j1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4j1o RCSB], [https://www.ebi.ac.uk/pdbsum/4j1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4j1o ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HPBD_PARDP HPBD_PARDP]] Catalyzes the 2-epimerization of trans-4-hydroxy-L-proline betaine (tHyp-B) to cis-4-hydroxy-D-proline betaine (cHyp-B). Is involved in a catabolic pathway that degrades tHyp-B to alpha-ketoglutarate. This pathway would permit the utilization of tHyp-B as a carbon and nitrogen source in the absence of osmotic stress, since tHyp-B functions as an osmolyte and is not catabolized when it is needed as osmoprotectant. Can also catalyze the racemization of L-proline betaine.<ref>PMID:24056934</ref>
[https://www.uniprot.org/uniprot/HPBD_PARDP HPBD_PARDP] Catalyzes the 2-epimerization of trans-4-hydroxy-L-proline betaine (tHyp-B) to cis-4-hydroxy-D-proline betaine (cHyp-B). Is involved in a catabolic pathway that degrades tHyp-B to alpha-ketoglutarate. This pathway would permit the utilization of tHyp-B as a carbon and nitrogen source in the absence of osmotic stress, since tHyp-B functions as an osmolyte and is not catabolized when it is needed as osmoprotectant. Can also catalyze the racemization of L-proline betaine.<ref>PMID:24056934</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Pardp]]
[[Category: Paracoccus denitrificans PD1222]]
[[Category: Almo, S C]]
[[Category: Almo SC]]
[[Category: Bhosle, R]]
[[Category: Bhosle R]]
[[Category: Bonanno, J B]]
[[Category: Bonanno JB]]
[[Category: Chamala, S]]
[[Category: Chamala S]]
[[Category: Evans, B]]
[[Category: Evans B]]
[[Category: Gerlt, J A]]
[[Category: Gerlt JA]]
[[Category: Gizzi, A]]
[[Category: Gizzi A]]
[[Category: Hammonds, J]]
[[Category: Hammonds J]]
[[Category: Hillerich, B]]
[[Category: Hillerich B]]
[[Category: Kar, A]]
[[Category: Kar A]]
[[Category: LaFleur, J]]
[[Category: LaFleur J]]
[[Category: Love, J]]
[[Category: Love J]]
[[Category: Morisco, L L]]
[[Category: Morisco LL]]
[[Category: Structural genomic]]
[[Category: Seidel RD]]
[[Category: Seidel, R D]]
[[Category: Sojitra S]]
[[Category: Sojitra, S]]
[[Category: Stead M]]
[[Category: Stead, M]]
[[Category: Toro R]]
[[Category: Toro, R]]
[[Category: Vetting MW]]
[[Category: Vetting, M W]]
[[Category: Villigas G]]
[[Category: Villigas, G]]
[[Category: Wasserman SR]]
[[Category: Wasserman, S R]]
[[Category: Betaine racemase]]
[[Category: Enolase]]
[[Category: Isomerase]]
[[Category: Nysgrc]]
[[Category: Proline betaine racemease]]
[[Category: Psi-biology]]

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