4ii1: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
No edit summary
No edit summary
Line 1: Line 1:


==Crystal structure of the zinc finger of ZGPAT==
==Crystal structure of the zinc finger of ZGPAT==
<StructureSection load='4ii1' size='340' side='right' caption='[[4ii1]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
<StructureSection load='4ii1' size='340' side='right'caption='[[4ii1]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ii1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4II1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4II1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ii1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4II1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4II1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZGPAT, GPATC6, GPATCH6, KIAA1847, ZC3H9, ZC3HDC9, ZIP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ii1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ii1 OCA], [https://pdbe.org/4ii1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ii1 RCSB], [https://www.ebi.ac.uk/pdbsum/4ii1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ii1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ii1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ii1 OCA], [http://pdbe.org/4ii1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ii1 RCSB], [http://www.ebi.ac.uk/pdbsum/4ii1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ii1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ZGPAT_HUMAN ZGPAT_HUMAN]] Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.<ref>PMID:19644445</ref>  Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.<ref>PMID:19644445</ref>
[https://www.uniprot.org/uniprot/ZGPAT_HUMAN ZGPAT_HUMAN] Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.<ref>PMID:19644445</ref>  Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.<ref>PMID:19644445</ref>  
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H]]
[[Category: Large Structures]]
[[Category: Bian, C]]
[[Category: Arrowsmith CH]]
[[Category: Bountra, C]]
[[Category: Bian C]]
[[Category: Chao, X]]
[[Category: Bountra C]]
[[Category: Dong, A]]
[[Category: Chao X]]
[[Category: Edwards, A M]]
[[Category: Dong A]]
[[Category: Fu, M]]
[[Category: Edwards AM]]
[[Category: Min, J]]
[[Category: Fu M]]
[[Category: Structural genomic]]
[[Category: Min J]]
[[Category: Tempel, W]]
[[Category: Tempel W]]
[[Category: Weigelt, J]]
[[Category: Weigelt J]]
[[Category: Wernimont, A K]]
[[Category: Wernimont AK]]
[[Category: Sgc]]
[[Category: Transcription]]
[[Category: Transcription regulation]]

Revision as of 23:46, 16 November 2022

Crystal structure of the zinc finger of ZGPATCrystal structure of the zinc finger of ZGPAT

Structural highlights

4ii1 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ZGPAT_HUMAN Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.[1] Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.[2]

References

  1. ↑ Li R, Zhang H, Yu W, Chen Y, Gui B, Liang J, Wang Y, Sun L, Yang X, Zhang Y, Shi L, Li Y, Shang Y. ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 2009 Sep 16;28(18):2763-76. doi: 10.1038/emboj.2009.211. Epub 2009 Jul, 30. PMID:19644445 doi:http://dx.doi.org/10.1038/emboj.2009.211
  2. ↑ Li R, Zhang H, Yu W, Chen Y, Gui B, Liang J, Wang Y, Sun L, Yang X, Zhang Y, Shi L, Li Y, Shang Y. ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 2009 Sep 16;28(18):2763-76. doi: 10.1038/emboj.2009.211. Epub 2009 Jul, 30. PMID:19644445 doi:http://dx.doi.org/10.1038/emboj.2009.211

4ii1, resolution 2.65Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=4ii1&oldid=3665368"