4ii1

Crystal structure of the zinc finger of ZGPATCrystal structure of the zinc finger of ZGPAT

Structural highlights

4ii1 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.65Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ZGPAT_HUMAN Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor. Able to suppress breast carcinogenesis.^[1] Isoform 4: Antagonizes the transcription repression by isoform 1 by competing for the binding of the NuRD complex. Does not bind DNA.^[2]

References

↑ Li R, Zhang H, Yu W, Chen Y, Gui B, Liang J, Wang Y, Sun L, Yang X, Zhang Y, Shi L, Li Y, Shang Y. ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 2009 Sep 16;28(18):2763-76. doi: 10.1038/emboj.2009.211. Epub 2009 Jul, 30. PMID:19644445 doi:http://dx.doi.org/10.1038/emboj.2009.211
↑ Li R, Zhang H, Yu W, Chen Y, Gui B, Liang J, Wang Y, Sun L, Yang X, Zhang Y, Shi L, Li Y, Shang Y. ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 2009 Sep 16;28(18):2763-76. doi: 10.1038/emboj.2009.211. Epub 2009 Jul, 30. PMID:19644445 doi:http://dx.doi.org/10.1038/emboj.2009.211

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OCA

[1] Li R, Zhang H, Yu W, Chen Y, Gui B, Liang J, Wang Y, Sun L, Yang X, Zhang Y, Shi L, Li Y, Shang Y. ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 2009 Sep 16;28(18):2763-76. doi: 10.1038/emboj.2009.211. Epub 2009 Jul, 30. PMID:19644445 doi:http://dx.doi.org/10.1038/emboj.2009.211

[2] Li R, Zhang H, Yu W, Chen Y, Gui B, Liang J, Wang Y, Sun L, Yang X, Zhang Y, Shi L, Li Y, Shang Y. ZIP: a novel transcription repressor, represses EGFR oncogene and suppresses breast carcinogenesis. EMBO J. 2009 Sep 16;28(18):2763-76. doi: 10.1038/emboj.2009.211. Epub 2009 Jul, 30. PMID:19644445 doi:http://dx.doi.org/10.1038/emboj.2009.211

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