3ui7: Difference between revisions
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==Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia== | ==Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia== | ||
<StructureSection load='3ui7' size='340' side='right' caption='[[3ui7]], [[Resolution|resolution]] 2.28Å' scene=''> | <StructureSection load='3ui7' size='340' side='right'caption='[[3ui7]], [[Resolution|resolution]] 2.28Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ui7]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3ui7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UI7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UI7 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C1L:6-METHOXY-3,8-DIMETHYL-4-(MORPHOLIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-B]QUINOLINE'>C1L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C1L:6-METHOXY-3,8-DIMETHYL-4-(MORPHOLIN-4-YLMETHYL)-1H-PYRAZOLO[3,4-B]QUINOLINE'>C1L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE10A ([ | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE10A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ui7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ui7 OCA], [https://pdbe.org/3ui7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ui7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ui7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ui7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[Phosphodiesterase|Phosphodiesterase]] | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Greenlee, W J]] | [[Category: Greenlee, W J]] | ||
[[Category: Ho, G]] | [[Category: Ho, G]] | ||