3ui7

Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophreniaDiscovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia

Structural highlights

3ui7 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.28Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PDE10_HUMAN Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.^[1]

References

↑ Wang H, Liu Y, Hou J, Zheng M, Robinson H, Ke H. Structural insight into substrate specificity of phosphodiesterase 10. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5782-7. Epub 2007 Mar 26. PMID:17389385

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OCA

[1] Wang H, Liu Y, Hou J, Zheng M, Robinson H, Ke H. Structural insight into substrate specificity of phosphodiesterase 10. Proc Natl Acad Sci U S A. 2007 Apr 3;104(14):5782-7. Epub 2007 Mar 26. PMID:17389385

[1]

3ui7

Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophreniaDiscovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia

Structural highlights

Function

See Also

References

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3ui7

Discovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophreniaDiscovery of orally active pyrazoloquinoline as a potent PDE10 inhibitor for the management of schizophrenia

Structural highlights

Function

See Also

References

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