3may: Difference between revisions
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==Crystal structure of a secreted Mycobacterium tuberculosis heme-binding protein== | ==Crystal structure of a secreted Mycobacterium tuberculosis heme-binding protein== | ||
<StructureSection load='3may' size='340' side='right' caption='[[3may]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='3may' size='340' side='right'caption='[[3may]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3may]] is a 8 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3may]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MAY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MAY FirstGlance]. <br> | ||
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT0213, Rv0203 ([ | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MT0213, Rv0203 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3may FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3may OCA], [https://pdbe.org/3may PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3may RCSB], [https://www.ebi.ac.uk/pdbsum/3may PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3may ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Chim, N]] | [[Category: Chim, N]] | ||
[[Category: Goulding, C W]] | [[Category: Goulding, C W]] | ||
[[Category: Helical protein]] | [[Category: Helical protein]] | ||
[[Category: Heme-binding protein]] | [[Category: Heme-binding protein]] | ||
Revision as of 16:45, 4 May 2022
Crystal structure of a secreted Mycobacterium tuberculosis heme-binding proteinCrystal structure of a secreted Mycobacterium tuberculosis heme-binding protein
Structural highlights
Publication Abstract from PubMedMycobacterium tuberculosis must import iron from its host for survival, and its siderophore-dependent iron acquisition pathways are well established. Here we demonstrate a newly characterized pathway, whereby M. tuberculosis can use free heme and heme from hemoglobin as an iron source. Significantly, we identified the genomic region, Rv0202c-Rv0207c, responsible for the passage of heme iron across the mycobacterial membrane. Key players of this heme uptake system were characterized including a secreted protein and two transmembrane proteins, all three specific to mycobacteria. Furthermore, the crystal structure of the key heme carrier protein Rv0203 was found to have a unique fold. The discovery of a unique mycobacterial heme acquisition pathway opens new avenues of exploration into mycobacterial therapeutics. Discovery and characterization of a unique mycobacterial heme acquisition system.,Tullius MV, Harmston CA, Owens CP, Chim N, Morse RP, McMath LM, Iniguez A, Kimmey JM, Sawaya MR, Whitelegge JP, Horwitz MA, Goulding CW Proc Natl Acad Sci U S A. 2011 Mar 7. PMID:21383189[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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