6sg8: Difference between revisions
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<StructureSection load='6sg8' size='340' side='right'caption='[[6sg8]], [[Resolution|resolution]] 2.50Å' scene=''> | <StructureSection load='6sg8' size='340' side='right'caption='[[6sg8]], [[Resolution|resolution]] 2.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6sg8]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6sg8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sosuga_virus Sosuga virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SG8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SG8 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sg8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sg8 OCA], [https://pdbe.org/6sg8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sg8 RCSB], [https://www.ebi.ac.uk/pdbsum/6sg8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sg8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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</div> | </div> | ||
<div class="pdbe-citations 6sg8" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6sg8" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 14:08, 30 March 2022
Structure of Sosuga virus receptor binding proteinStructure of Sosuga virus receptor binding protein
Structural highlights
Publication Abstract from PubMedThe bat-borne paramyxovirus, Sosuga virus (SosV), is one of many paramyxoviruses recently identified and classified within the newly established genus Pararubulavirus, family Paramyxoviridae The envelope surface of SosV presents a receptor-binding protein (RBP), SosV-RBP, which facilitates host-cell attachment and entry. Unlike closely related hemagglutinin neuraminidase RBPs from other genera of the Paramyxoviridae, SosV-RBP and other pararubulavirus RBPs lack many of the stringently conserved residues required for sialic acid recognition and hydrolysis. We determined the crystal structure of the globular head region of SosV-RBP, revealing that while the glycoprotein presents a classical paramyxoviral six-bladed beta-propeller fold and structurally classifies in close proximity to paramyxoviral RBPs with hemagglutinin-neuraminidase (HN) functionality, it presents a receptor-binding face incongruent with sialic acid recognition. Hemadsorption and neuraminidase activity analysis confirms the limited capacity of SosV-RBP to interact with sialic acid in vitro and indicates that SosV-RBP undergoes a nonclassical route of host-cell entry. The close overall structural conservation of SosV-RBP with other classical HN RBPs supports a model by which pararubulaviruses only recently diverged from sialic acid binding functionality. A structure-based rationale for sialic acid independent host-cell entry of Sosuga virus.,Stelfox AJ, Bowden TA Proc Natl Acad Sci U S A. 2019 Oct 7. pii: 1906717116. doi:, 10.1073/pnas.1906717116. PMID:31591233[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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