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==Crystal structure of TcOYE with pHBA==
==Crystal structure of TcOYE with pHBA==
<StructureSection load='3atz' size='340' side='right' caption='[[3atz]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
<StructureSection load='3atz' size='340' side='right'caption='[[3atz]], [[Resolution|resolution]] 2.04&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3atz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ATZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ATZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[3atz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ATZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ATZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=HBA:P-HYDROXYBENZALDEHYDE'>HBA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=HBA:P-HYDROXYBENZALDEHYDE'>HBA</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3aty|3aty]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3aty|3aty]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TcPGFS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TcPGFS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5693 TRYCR])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3atz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3atz OCA], [http://pdbe.org/3atz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3atz RCSB], [http://www.ebi.ac.uk/pdbsum/3atz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3atz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3atz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3atz OCA], [https://pdbe.org/3atz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3atz RCSB], [https://www.ebi.ac.uk/pdbsum/3atz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3atz ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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</div>
</div>
<div class="pdbe-citations 3atz" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3atz" style="background-color:#fffaf0;"></div>
==See Also==
*[[NADPH dehydrogenase|NADPH dehydrogenase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Trycr]]
[[Category: Trycr]]
[[Category: Inaka, K]]
[[Category: Inaka, K]]

Revision as of 18:04, 29 December 2021

Crystal structure of TcOYE with pHBACrystal structure of TcOYE with pHBA

Structural highlights

3atz is a 4 chain structure with sequence from Trycr. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Gene:TcPGFS (TRYCR)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

Old yellow enzyme (OYE) is an NADPH oxidoreductase capable of reducing a variety of compounds. It contains flavin mononucleotide (FMN) as a prosthetic group. A ternary complex structure of OYE from Trypanosoma cruzi (TcOYE) with FMN and one of the substrates, p-hydroxybenzaldehyde, shows a striking movement around the active site upon binding of the substrate. From a structural comparison of other OYE complexed with 12-oxophytodienoate, we have constructed a complex structure with another substrate, prostaglandin H(2) (PGH(2)), to provide a proposed stereoselective reaction mechanism for the reduction of PGH(2) to prostaglandin F(2alpha) by TcOYE.

Structural insight into the stereoselective production of PGF2alpha by Old Yellow Enzyme from Trypanosoma cruzi.,Okamoto N, Yamaguchi K, Mizohata E, Tokuoka K, Uchiyama N, Sugiyama S, Matsumura H, Inaka K, Urade Y, Inoue T J Biochem. 2011 Nov;150(5):563-8. doi: 10.1093/jb/mvr096. Epub 2011 Aug, 12. PMID:21840922[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. ↑ Okamoto N, Yamaguchi K, Mizohata E, Tokuoka K, Uchiyama N, Sugiyama S, Matsumura H, Inaka K, Urade Y, Inoue T. Structural insight into the stereoselective production of PGF2alpha by Old Yellow Enzyme from Trypanosoma cruzi. J Biochem. 2011 Nov;150(5):563-8. doi: 10.1093/jb/mvr096. Epub 2011 Aug, 12. PMID:21840922 doi:10.1093/jb/mvr096

3atz, resolution 2.04Å

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