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==Solution structure of the SH3 domain of mouse RUN and TBC1 domain containing 3==
==Solution structure of the SH3 domain of mouse RUN and TBC1 domain containing 3==
<StructureSection load='2yuo' size='340' side='right' caption='[[2yuo]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2yuo' size='340' side='right'caption='[[2yuo]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2yuo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YUO FirstGlance]. <br>
<table><tr><td colspan='2'>[[2yuo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YUO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YUO FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rutbc3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rutbc3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yuo OCA], [http://pdbe.org/2yuo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yuo RCSB], [http://www.ebi.ac.uk/pdbsum/2yuo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yuo ProSAT], [http://www.topsan.org/Proteins/RSGI/2yuo TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yuo OCA], [https://pdbe.org/2yuo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yuo RCSB], [https://www.ebi.ac.uk/pdbsum/2yuo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yuo ProSAT], [https://www.topsan.org/Proteins/RSGI/2yuo TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SGSM3_MOUSE SGSM3_MOUSE]] May play a cooperative role in NF2-mediated growth suppression of cells (By similarity).<ref>PMID:17509819</ref> [UniProtKB:Q96HU1]  
[[https://www.uniprot.org/uniprot/SGSM3_MOUSE SGSM3_MOUSE]] May play a cooperative role in NF2-mediated growth suppression of cells (By similarity).<ref>PMID:17509819</ref> [UniProtKB:Q96HU1]  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Lk3 transgenic mice]]
[[Category: Abe, H]]
[[Category: Abe, H]]

Revision as of 13:40, 8 December 2021

Solution structure of the SH3 domain of mouse RUN and TBC1 domain containing 3Solution structure of the SH3 domain of mouse RUN and TBC1 domain containing 3

Structural highlights

2yuo is a 1 chain structure with sequence from Lk3 transgenic mice. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:Rutbc3 (LK3 transgenic mice)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

[SGSM3_MOUSE] May play a cooperative role in NF2-mediated growth suppression of cells (By similarity).[1] [UniProtKB:Q96HU1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Yang H, Sasaki T, Minoshima S, Shimizu N. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. Genomics. 2007 Aug;90(2):249-60. Epub 2007 May 23. PMID:17509819 doi:http://dx.doi.org/S0888-7543(07)00070-5
Drag the structure with the mouse to rotate

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OCA
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