6lr0: Difference between revisions

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<StructureSection load='6lr0' size='340' side='right'caption='[[6lr0]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
<StructureSection load='6lr0' size='340' side='right'caption='[[6lr0]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6lr0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LR0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6LR0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6lr0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LR0 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABCB11, BSEP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABCB11, BSEP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6lr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lr0 OCA], [http://pdbe.org/6lr0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6lr0 RCSB], [http://www.ebi.ac.uk/pdbsum/6lr0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6lr0 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lr0 OCA], [https://pdbe.org/6lr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lr0 RCSB], [https://www.ebi.ac.uk/pdbsum/6lr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lr0 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/ABCBB_HUMAN ABCBB_HUMAN]] Progressive familial intrahepatic cholestasis type 2;Intrahepatic cholestasis of pregnancy;Benign recurrent intrahepatic cholestasis type 2. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  
[[https://www.uniprot.org/uniprot/ABCBB_HUMAN ABCBB_HUMAN]] Progressive familial intrahepatic cholestasis type 2;Intrahepatic cholestasis of pregnancy;Benign recurrent intrahepatic cholestasis type 2. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ABCBB_HUMAN ABCBB_HUMAN]] Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner (PubMed:16332456). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456).<ref>PMID:16332456</ref>   
[[https://www.uniprot.org/uniprot/ABCBB_HUMAN ABCBB_HUMAN]] Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner (PubMed:16332456). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456).<ref>PMID:16332456</ref>   
== References ==
== References ==
<references/>
<references/>

Revision as of 09:12, 11 August 2021

structure of human bile salt exporter ABCB11structure of human bile salt exporter ABCB11

Structural highlights

6lr0 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:ABCB11, BSEP (HUMAN)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[ABCBB_HUMAN] Progressive familial intrahepatic cholestasis type 2;Intrahepatic cholestasis of pregnancy;Benign recurrent intrahepatic cholestasis type 2. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

[ABCBB_HUMAN] Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner (PubMed:16332456). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456).[1]

References

  1. ↑ Hayashi H, Takada T, Suzuki H, Onuki R, Hofmann AF, Sugiyama Y. Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep. Biochim Biophys Acta. 2005 Dec 30;1738(1-3):54-62. doi:, 10.1016/j.bbalip.2005.10.006. Epub 2005 Nov 15. PMID:16332456 doi:http://dx.doi.org/10.1016/j.bbalip.2005.10.006

6lr0, resolution 3.50Å

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