6lr0

structure of human bile salt exporter ABCB11structure of human bile salt exporter ABCB11

Structural highlights

6lr0 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

ABCBB_HUMAN Progressive familial intrahepatic cholestasis type 2;Intrahepatic cholestasis of pregnancy;Benign recurrent intrahepatic cholestasis type 2. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

ABCBB_HUMAN Catalyzes the secretion of conjugated bile salts across the canalicular membrane of hepatocytes in an ATP-dependent manner (PubMed:16332456). Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts (PubMed:16332456).^[1]

References

↑ Hayashi H, Takada T, Suzuki H, Onuki R, Hofmann AF, Sugiyama Y. Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep. Biochim Biophys Acta. 2005 Dec 30;1738(1-3):54-62. doi:, 10.1016/j.bbalip.2005.10.006. Epub 2005 Nov 15. PMID:16332456 doi:http://dx.doi.org/10.1016/j.bbalip.2005.10.006

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OCA

[1] Hayashi H, Takada T, Suzuki H, Onuki R, Hofmann AF, Sugiyama Y. Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep. Biochim Biophys Acta. 2005 Dec 30;1738(1-3):54-62. doi:, 10.1016/j.bbalip.2005.10.006. Epub 2005 Nov 15. PMID:16332456 doi:http://dx.doi.org/10.1016/j.bbalip.2005.10.006

[1]

6lr0

structure of human bile salt exporter ABCB11structure of human bile salt exporter ABCB11

Structural highlights

Disease

Function

References

Contents

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6lr0

structure of human bile salt exporter ABCB11structure of human bile salt exporter ABCB11

Structural highlights

Disease

Function

References

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