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==Crystal structure of glutamate dehydrogenase 3 from Candida albicans== | ==Crystal structure of glutamate dehydrogenase 3 from Candida albicans== | ||
<StructureSection load='7f77' size='340' side='right'caption='[[7f77]]' scene=''> | <StructureSection load='7f77' size='340' side='right'caption='[[7f77]], [[Resolution|resolution]] 3.09Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F77 FirstGlance]. <br> | <table><tr><td colspan='2'>[[7f77]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Canal Canal]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7F77 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7F77 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f77 OCA], [https://pdbe.org/7f77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f77 RCSB], [https://www.ebi.ac.uk/pdbsum/7f77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f77 ProSAT]</span></td></tr> | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GDH3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=237561 CANAL])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7f77 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7f77 OCA], [https://pdbe.org/7f77 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7f77 RCSB], [https://www.ebi.ac.uk/pdbsum/7f77 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7f77 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Glutamate dehydrogenase 3 from Candida albicans (CaGdh3) catalyzes the reversible oxidative deamination of l-glutamate, playing an important role in the yeast-to-hyphal transition of C. albicans. Here we report the crystal structures of CaGdh3 and its complex with alpha-ketoglutarate and NADPH. CaGdh3 exists as a hexamer, with each subunit containing two domains. The substrate and coenzyme bind in the cleft between the two domains and their binding induces a conformational change in CaGdh3. Our results will help to understand the catalytic mechanism of CaGdh3 and will provide a structural basis for the design of antifungal drugs targeting the CaGdh3 pathway. | |||
Crystal structure of glutamate dehydrogenase 3 from Candida albicans.,Li N, Wang W, Zeng X, Liu M, Li M, Li C, Wang M Biochem Biophys Res Commun. 2021 Jul 13;570:15-20. doi:, 10.1016/j.bbrc.2021.07.014. PMID:34271431<ref>PMID:34271431</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7f77" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Canal]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Li C]] | [[Category: Li, C]] | ||
[[Category: Li M]] | [[Category: Li, M]] | ||
[[Category: Li N]] | [[Category: Li, N]] | ||
[[Category: Liu M]] | [[Category: Liu, M]] | ||
[[Category: Wang M]] | [[Category: Wang, M]] | ||
[[Category: Wang W]] | [[Category: Wang, W]] | ||
[[Category: Zeng X]] | [[Category: Zeng, X]] | ||
[[Category: Candida albican]] | |||
[[Category: Conformational change]] | |||
[[Category: Glutamate dehydrogenase]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: Yeast-to-hyphal transition]] | |||
Revision as of 13:48, 28 July 2021
Crystal structure of glutamate dehydrogenase 3 from Candida albicansCrystal structure of glutamate dehydrogenase 3 from Candida albicans
Structural highlights
Publication Abstract from PubMedGlutamate dehydrogenase 3 from Candida albicans (CaGdh3) catalyzes the reversible oxidative deamination of l-glutamate, playing an important role in the yeast-to-hyphal transition of C. albicans. Here we report the crystal structures of CaGdh3 and its complex with alpha-ketoglutarate and NADPH. CaGdh3 exists as a hexamer, with each subunit containing two domains. The substrate and coenzyme bind in the cleft between the two domains and their binding induces a conformational change in CaGdh3. Our results will help to understand the catalytic mechanism of CaGdh3 and will provide a structural basis for the design of antifungal drugs targeting the CaGdh3 pathway. Crystal structure of glutamate dehydrogenase 3 from Candida albicans.,Li N, Wang W, Zeng X, Liu M, Li M, Li C, Wang M Biochem Biophys Res Commun. 2021 Jul 13;570:15-20. doi:, 10.1016/j.bbrc.2021.07.014. PMID:34271431[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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