7f77

Crystal structure of glutamate dehydrogenase 3 from Candida albicansCrystal structure of glutamate dehydrogenase 3 from Candida albicans

Structural highlights 7f77 is a 3 chain structure with sequence from Candida albicans SC5314. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.086Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A1D8PMH8_CANAL Publication Abstract from PubMed Glutamate dehydrogenase 3 from Candida albicans (CaGdh3) catalyzes the reversible oxidative deamination of l-glutamate, playing an important role in the yeast-to-hyphal transition of C. albicans. Here we report the crystal structures of CaGdh3 and its complex with alpha-ketoglutarate and NADPH. CaGdh3 exists as a hexamer, with each subunit containing two domains. The substrate and coenzyme bind in the cleft between the two domains and their binding induces a conformational change in CaGdh3. Our results will help to understand the catalytic mechanism of CaGdh3 and will provide a structural basis for the design of antifungal drugs targeting the CaGdh3 pathway. Crystal structure of glutamate dehydrogenase 3 from Candida albicans.,Li N, Wang W, Zeng X, Liu M, Li M, Li C, Wang M Biochem Biophys Res Commun. 2021 Jul 13;570:15-20. doi:, 10.1016/j.bbrc.2021.07.014. PMID:34271431 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Glutamate dehydrogenase 3D structures

spinqualitylabelsall models 7f77, resolution 3.09Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image