1ef5: Difference between revisions

Revision as of 15:01, 2 May 2008

SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF RGL

OverviewOverview

The RGL protein, a homolog of the Ral GDP dissociation stimulator (RalGDS), has been identified as a downstream effector of Ras. In the present study, the solution structure of the Ras-binding domain of RGL (RGL-RBD) was determined by NMR spectroscopy. The overall fold of RGL-RBD consists of a five-stranded beta-sheet and two alpha-helices, which is the same topology as that of RalGDS-RBD. The backbone chemical shift perturbation of RGL-RBD upon interaction with the GTP analog-bound Ras was also examined. The solution structure of RGL-RBD, especially around some of the Ras-interacting residues, is appreciably different from that of RalGDS-RBD.

About this StructureAbout this Structure

1EF5 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

ReferenceReference

Solution structure of the Ras-binding domain of RGL., Kigawa T, Endo M, Ito Y, Shirouzu M, Kikuchi A, Yokoyama S, FEBS Lett. 1998 Dec 28;441(3):413-8. PMID:9891982 Page seeded by OCA on Fri May 2 15:01:21 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1ef5.jpg|left|200px]]
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 '''SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF RGL'''
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 [[Category: Shirouzu, M.]]
 [[Category: Yokoyama, S.]]
-[[Category: ra]]
+[[Category: Ra]]
-[[Category: ra]]
+[[Category: Ra]]
-[[Category: ras-binding domain]]
+[[Category: Ras-binding domain]]
-[[Category: rbd]]
+[[Category: Rbd]]
-[[Category: rgl]]
+[[Category: Rgl]]
-[[Category: riken structural genomics/proteomics initiative]]
+[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: rsgi]]
+[[Category: Rsgi]]
-[[Category: structural genomic]]
+[[Category: Structural genomic]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 15:01:21 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 20:01:30 2008''