1ef5

SOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF RGLSOLUTION STRUCTURE OF THE RAS-BINDING DOMAIN OF RGL

Structural highlights 1ef5 is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN Function RGL1_MOUSE Probable guanine nucleotide exchange factor. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The RGL protein, a homolog of the Ral GDP dissociation stimulator (RalGDS), has been identified as a downstream effector of Ras. In the present study, the solution structure of the Ras-binding domain of RGL (RGL-RBD) was determined by NMR spectroscopy. The overall fold of RGL-RBD consists of a five-stranded beta-sheet and two alpha-helices, which is the same topology as that of RalGDS-RBD. The backbone chemical shift perturbation of RGL-RBD upon interaction with the GTP analog-bound Ras was also examined. The solution structure of RGL-RBD, especially around some of the Ras-interacting residues, is appreciably different from that of RalGDS-RBD. Solution structure of the Ras-binding domain of RGL.,Kigawa T, Endo M, Ito Y, Shirouzu M, Kikuchi A, Yokoyama S FEBS Lett. 1998 Dec 28;441(3):413-8. PMID:9891982 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

spinqualitylabelsall models 1ef5 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image