Stimulator of interferon genes protein: Difference between revisions

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 == Function ==
-'''Stimulator of interferon genes protein''' or '''transmembrane protein 173''' (STING) is involved in the third step of the biosynthesis of lipid A which is a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.  Thus, LpxD is essential to survival of Gram-negative bacteria.  It catalyzes the N-acylation of UDP-3-O-(3-hydroxytetradeanoyl)glucosamine<ref>PMID:18456814</ref>. LpxD is structurally similar to LpxA which functions as the first enzye in the lipid A biosynthesis.
+'''Stimulator of interferon genes protein''' or '''transmembrane protein 173''' (STING) is an ER-associated membrane protein.  STING signals immune responses in human and other animals. STING is activated by cyclic GMP-AMP produced by cyclic GMP-AMP synthase whose activity is triggered by infections of DNA-containing pathogens<ref>PMID:30842659</ref>. A PLPLRT/SD conserved motif at the STING C-terminal plays a critical role in turning on the immune system to fight against viral infections<ref>PMID:31118511</ref>.
 == Relevance ==
-LpxD inhibitors are antimicrobials<ref>PMID:22530734</ref>.
+STING mutations are associated with autoimmune diseases<ref>PMID:26235147</ref>.
 == Structural highlights ==