Signal recognition particle protein: Difference between revisions

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*Signal recognition particle
*Signal recognition particle


**[[1qb2]] – hSRP54 - human<br />
**[[4p3f]] – hSRP68 (mutant)<br />
**[[5m72]], [[5wrv]] – hSRP68 + SRP72<br />
**[[5wrw]] – hSRP72<br />
**[[1914]] – mSRP9/SRP14 – mouse<br />
**[[1914]] – mSRP9/SRP14 – mouse<br />
**[[1wgw]] – mSRP54 N terminal – NMR<br />
**[[1wgw]] – mSRP54 N terminal – NMR<br />
**[[1ls1]], [[2j45]], [[2j46]], [[1ffh]], [[1ng1]], [[3ng1]] - TaSRP54-like NG domain – ''Thermus aquaticus''<br />
**[[2ng1]] - TaSRP54-like NG domain (mutant)<br />
**[[2ffh]] - TaSRP54-like residues 1-425 (mutant)<br />
**[[1kvn]], [[1kvv]] – SRP19 (mutant) – ''Archaeoglobus fulgidus'' – NMR<BR />
**[[1qb2]] – hSRP54 <br />
**[[2hug]] – AtSRP43 chromodomain 2 + SRP54 M domain – ''Arabidopsis thaliana'' – NMR<BR />
**[[2hug]] – AtSRP43 chromodomain 2 + SRP54 M domain – ''Arabidopsis thaliana'' – NMR<BR />
**[[1x32]] - AtSRP43 chromodomain 1 – NMR<br />
**[[1x32]] - AtSRP43 chromodomain 1 – NMR<br />
Line 21: Line 20:
**[[3deo]] - AtSRP43 residues 85-267<br />
**[[3deo]] - AtSRP43 residues 85-267<br />
**[[3ui2]] - AtSRP43 residues 84-327 + AtSRP54 RRKR motif<br />
**[[3ui2]] - AtSRP43 residues 84-327 + AtSRP54 RRKR motif<br />
**[[2w9j]] – SRP14 residues 1-91 – fission yeast<br />
**[[1ls1]], [[2j45]], [[2j46]], [[1ffh]], [[1ng1]], [[3ng1]] - TaSRP54-like NG domain – ''Thermus aquaticus''<br />
**[[2ng1]] - TaSRP54-like NG domain (mutant)<br />
**[[2ffh]] - TaSRP54-like residues 1-425 (mutant)<br />
**[[1kvn]], [[1kvv]] – SRP19 (mutant) – ''Archaeoglobus fulgidus'' – NMR<BR />
**[[3dlu]], [[3dlv]], [[3dm5]] – SRP19 – ''Pyrococcus furiosus''<br />
**[[3dlu]], [[3dlv]], [[3dm5]] – SRP19 – ''Pyrococcus furiosus''<br />
**[[2w9j]] – SRP14 residues 1-91 – fission yeast<br />
**[[1j8m]] – AaSPR GTPase domain – ''Acicianus ambivalens''<br />
**[[1j8m]] – AaSPR GTPase domain – ''Acicianus ambivalens''<br />
**[[1j8y]] – AaSPR GTPase domain (mutant)<br />
**[[1j8y]] – AaSPR GTPase domain (mutant)<br />
**[[1qzx]] – SsSRP54 – ''Sulfolobus solfataricus''<br />
**[[1qzx]] – SsSRP54 – ''Sulfolobus solfataricus''<br />
**[[4p3f]] – hSRP68 (mutant) – human<br />
**[[5m72]], [[5wrv]] – hSRP68 + SRP72<br />
**[[5wrw]] – hSRP72<br />


*Signal recognition particle complexes with RNA
*Signal recognition particle complexes with RNA
Line 38: Line 38:
**[[1jid]] – hSRP19 + RNA<br />
**[[1jid]] – hSRP19 + RNA<br />
**[[3ktv]] - hSRP19 + RNA S domain<br />
**[[3ktv]] - hSRP19 + RNA S domain<br />
**[[1mfq]] – hSRP19 + hSRP54 M domain + 7S RNA S domain<br />
**[[2j37]] - hSRP19 + SRP54 + ribosomal proteins L23, L31, L35 + RNA – Cryo EM<BR />
**[[2go5]] – dSRP19 + SRP54 + hSRP receptor α subunit + mSRP receptor b subunit + ribosomal proteins L23, L31, L35 + RNA – dog<br />
**[[4ue5]] – dSRP9 + SRP14 + SRP54 + SRP68 + RNA – Cryo EM<br />
**[[3ktw]] - SsSRP19 + RNA S domain <br />
**[[3ktw]] - SsSRP19 + RNA S domain <br />
**[[1qzw]] – SsSRP + 7S RNA<br />
**[[1qzw]] – SsSRP + 7S RNA<br />
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**[[1l9a]] - MjSRP19 (mutant) + RNA<br />
**[[1l9a]] - MjSRP19 (mutant) + RNA<br />
**[[2v3c]], [[3ndb]], [[4xco]] - MjSRP19 + MjSRP54 + 7S RNA<br />
**[[2v3c]], [[3ndb]], [[4xco]] - MjSRP19 + MjSRP54 + 7S RNA<br />
**[[1mfq]] – hSRP19 + hSRP54 M domain + 7S RNA S domain<br />
**[[2iy3]] – TaSRP54-like + RNA - EM<BR />
**[[2iy3]] – TaSRP54-like + RNA - EM<BR />
**[[1dul]], [[1hq1]], [[2pxp]] – EcSRP54-like C terminal + RNA – ''Escherichia coli''<br />
**[[1dul]], [[1hq1]], [[2pxp]] – EcSRP54-like C terminal + RNA – ''Escherichia coli''<br />
**[[3lqx]] - EcSRP54-like + RNA + Co-hexamine<br />
**[[3lqx]] - EcSRP54-like + RNA + Co-hexamine<br />
**[[2xkv]] - EcSRP54-like NG+M domains + 4.5SRNA – EM<BR />
**[[2xkv]] - EcSRP54-like NG+M domains + 4.5SRNA – Cryo EM<BR />
**[[2xxa]] - EcSRP54-like residues 1-433 (mutant) + cell division protein FtsY residues 196-497+ 4.5SRNA<br />
**[[2xxa]] - EcSRP54-like residues 1-433 (mutant) + cell division protein FtsY residues 196-497+ 4.5SRNA<br />
**[[3zn8]] - EcSRP54 NG domain + cell division protein FtsY residues 201-495+ 4.5SRNA + dipeptidyl aminopeptidase B<br />
**[[3zn8]] - EcSRP54 NG domain + cell division protein FtsY residues 201-495+ 4.5SRNA + dipeptidyl aminopeptidase B<br />
**[[2pxb]], [[2pxd]], [[2pxe]], [[2pxf]], [[2pxk]], [[2pxl]], [[2pxq]], [[2pxq]], [[2pxt]], [[2pxu]], [[2pxv]] - EcSRP54-like C terminal + 4.5SRNA domain IV (mutant)<br />
**[[2pxb]], [[2pxd]], [[2pxe]], [[2pxf]], [[2pxk]], [[2pxl]], [[2pxq]], [[2pxq]], [[2pxt]], [[2pxu]], [[2pxv]] - EcSRP54-like C terminal + 4.5SRNA domain IV (mutant)<br />
**[[2go5]] – dSRP19 + SRP54 + hSRP receptor α subunit + mSRP receptor b subunit + ribosomal proteins L23, L31, L35 + RNA – dog<br />
**[[4ue5]] – dSRP9 + SRP14 + SRP54 + SRP68 + RNA – Cryo EM<br />
**[[2j28]] – EcSRP54-like + 70S ribosome  – Cryo EM<BR />
**[[2j28]] – EcSRP54-like + 70S ribosome  – Cryo EM<BR />
**[[2j37]] - SRP19 + SRP54 + ribosomal proteins L23, L31, L35 + RNA – wheat – Cryo EM<BR />
**[[4ue4]] – SRP M domain + FTSQ signal sequence + RNA - ''Bacillus subtilis''<br />
**[[4ue4]] – SRP M domain + FTSQ signal sequence + RNA - ''Bacillus subtilis''<br />


*Other signal recognition particle complexes
*Other signal recognition particle complexes


**[[5l3q]] – hSRP54 + SRP receptor subunit α<br />
**[[3dep]] - AtSRP43 residues 85-267 + polypeptide<br />
**[[5e4w]] - AtSRP43 chromodomain 2-3 + thioredoxin + ALB3 tail<br />
**[[5l3r]] - AtSRP54 + cell division protein FTSY<br />
**[[1jpj]], [[1jpn]], [[2c04]] – TaSRP54-like NG domain + GMPPNP<BR />  
**[[1jpj]], [[1jpn]], [[2c04]] – TaSRP54-like NG domain + GMPPNP<BR />  
**[[1o87]], [[2c03]] - TaSRP54-like NG domain + GDP<br />
**[[1o87]], [[2c03]] - TaSRP54-like NG domain + GDP<br />
**[[1okk]], [[1rj9]], [[2cnw]] - TaSRP54-like NG domain + cell division protein FTSY<br />
**[[1okk]], [[1rj9]], [[2cnw]] - TaSRP54-like NG domain + cell division protein FTSY<br />
**[[2j7p]] - TaSRP54-like NG domain + cell division protein FTSY + GMPPNP<BR />
**[[2j7p]] - TaSRP54-like NG domain + cell division protein FTSY + GMPPNP<BR />
**[[3dep]] - AtSRP43 residues 85-267 + polypeptide<br />
**[[5e4w]] - AtSRP43 chromodomain 2-3 + thioredoxin + ALB3 tail<br />
**[[5l3r]] - AtSRP54 + cell division protein FTSY<br />
**[[5l3s]] - SsSRP54 + cell division protein FTSY<br />
**[[5l3s]] - SsSRP54 + cell division protein FTSY<br />
**[[3kl4]] – SsSRP54 residues 2-432 + polypeptide<br />
**[[3kl4]] – SsSRP54 residues 2-432 + polypeptide<br />
**[[5l3v]] - SsSRP54 + GDP<br />
**[[5l3v]] - SsSRP54 + GDP<br />
**[[4c7o]] – EcSRP + FTSY + SRP RNA<br />
**[[4c7o]] – EcSRP + FTSY + SRP RNA<br />
**[[5l3q]] – hSRP54 + SRP receptor subunit α<br />
 
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 14:35, 4 November 2020

Signal recognition particle (SRP) is a ribonucleoprotein which targets specific proteins to the endoplasmic reticulum (ER) in eukaryotes and the plasma membrane in prokaryotes. In eukaryotes SRP binds to the signal sequence of a newly synthesized polypeptide as it emerges from the ribosome. The binding allows for the coupling of the translation process to the translocation process. The SRP targets the nascent protein to the ER by docking into the SRP receptor[1]. The eukaryotic SRP which has GTPase activity, is composed of SRP9, SRP14[2], SRP19[3], SRP54[4], SRP68, SRP72[5] and 7S RNA. The prokaryotic SRP is composed of FFH (SRP54-like) and 4.5S RNA.

Human SRP9 (grey and pink) +SRP14 (green and yellow) complex with 7S RNA, GDP and sulfate 1e8o

Drag the structure with the mouse to rotate

3D structures of signal recognition particle3D structures of signal recognition particle

Updated on 04-November-2020

ReferencesReferences

  1. ↑ Halic M, Beckmann R. The signal recognition particle and its interactions during protein targeting. Curr Opin Struct Biol. 2005 Feb;15(1):116-25. PMID:15718142 doi:http://dx.doi.org/10.1016/j.sbi.2005.01.013
  2. ↑ Bovia F, Fornallaz M, Leffers H, Strub K. The SRP9/14 subunit of the signal recognition particle (SRP) is present in more than 20-fold excess over SRP in primate cells and exists primarily free but also in complex with small cytoplasmic Alu RNAs. Mol Biol Cell. 1995 Apr;6(4):471-84. PMID:7542942
  3. ↑ Dean KA, von Ahsen O, Gorlich D, Fried HM. Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin. J Cell Sci. 2001 Oct;114(Pt 19):3479-85. PMID:11682607
  4. ↑ Gowda K, Black SD, Moeller I, Sakakibara Y, Liu MC, Zwieb C. Protein SRP54 of human signal recognition particle: cloning, expression, and comparative analysis of functional sites. Gene. 1998 Jan 30;207(2):197-207. PMID:9511762
  5. ↑ Lutcke H, Prehn S, Ashford AJ, Remus M, Frank R, Dobberstein B. Assembly of the 68- and 72-kD proteins of signal recognition particle with 7S RNA. J Cell Biol. 1993 Jun;121(5):977-85. PMID:8388879

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Michal Harel, Alexander Berchansky
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