Cell death protein: Difference between revisions

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[[Cell death protein 3D structures]]
[[Cell death protein 3D structures]]
</StructureSection>
</StructureSection>
==3D structures of cell death protein==


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
*CED-1
**[[3rrq]], [[6umu]], [[6umv]] - hCED-1 extracellular domain (mutant) - human<br />
**[[2m2d]] - hCED-1 extracellular domain - NMR<br />
**[[5wt9]], [[5jxe]], [[5b8c]] - hCED-1 extracellular domain + antibody<br />
**[[5ggs]], [[5ggr]], [[6hig]], [[6j14]], [[6j15]], [[6jbt]], [[6jjp]], [[6k0y]], [[7bxa]]  - hCED-1 extracellular domain (mutant) + antibody<br />
**[[4zqk]], [[5ius]] - hCED-1 extracellular domain (mutant) + hCED-L1<br />
**[[6umt]] - hCED-1 extracellular domain (mutant) + hCED-L2 extracellular domain<br />
**[[1npu]] – mCED-1 extracellular domain (mutant) - mouse<br />
**[[3bik]] - mCED-1 extracellular domain (mutant) + hCED-L1 extracellular domain<br />
**[[3sbw]] - mCED-1 extracellular domain + hCED-L1 extracellular domain<br />
**[[3rnq]] - mCED-1 extracellular domain + mCED-L2 extracellular domain<br />
**[[3bp5]], [[3bp6]] - mCED-1 extracellular domain (mutant) + mCED-L2 extracellular domain<br />
**[[3rnk]] - mCED-1 extracellular domain (mutant) + mCED-L2 IgV domain<br />
*CED-2
**[[3qwx]], [[3qwy]] - CeCED-2 – ''Caenorhabditis elegans''
*CED-3
**[[4m9r]] - nCED-3 - nematode<br />
*CED-4
**[[2ggf]] – hCED-4 MA3 domain – NMR<BR />
**[[2rg8]], [[2kzt]] - hCED-4 MA3 domain<BR />
**[[3eij]] - hCED-4 residues 157-469<BR />
**[[2zu6]], [[3eiq]] - hCED-4 residues 163-469 + eukaryotic initiation factor 4A-I<br />
**[[2iol]], [[2ion]], [[2ios]], [[2nsz]] - mCED-4 MA3 domain<BR />
**[[2hm8]] - mCED-4 MA3 domain – NMR<BR />
**[[4m9s]], [[4m9x]], [[4m9y]], [[4m9z]] - nCED-4 + nCED-3 fragment<br />
**[[2a5y]] - CeCED-4 + CeCED-9 <BR />
**[[3lqq]], [[3lqr]] - CeCED-4<BR />
*CED-5
**[[1yyb]] - hCED-5 N terminal – NMR<BR />
**[[2cru]], [[2k6b]] - hCED-5 – NMR<BR />
*CED-6
**[[2zn8]], [[2zn9]], [[2znd]], [[2zrs]], [[2zrt]] - hCED-6<br />
**[[3aaj]], [[3aak]] - hCED-6 (mutant)<br />
**[[2zne]] - hCED-6 + CED-6-interacting protein<br />
**[[3wxa]] - hCED-6 + SEC31A peptide<br />
**[[5gqq]] - hCED-6 + heme-binding protein<br />
**[[1hqv]] - mCED-6<br />
**[[1y1x]] - CED-6 – ''Leishmania major''<br />
*CED-8 (apoptosis-inducing factor 1)
**[[1m6i]], [[4bv6]], [[4lii]] - hCED-8<br />
**[[5fmh]], [[5kvh]], [[5kvi]], [[5fs6]], [[5fs7]], [[5fs8]], [[4fdc]] – hCED-8 (mutant)  <br />
**[[5fs9]] – hCED-8 (mutant)  + FAD<br />
**[[4bur]] – hCED-8 + NAD <br />
**[[1gv4]], [[3gd3]] - mCED-8<br />
**[[3gd4]] – mCED-8 + NAD <br />
**[[5miu]] – mCED-8 (mutant) + FAD <br />
**[[5miv]] – mCED-8 (mutant) + FAD + NAD<br />
*CED-9
**[[1ohu]] – CeCED-9 <BR />
**[[1ty4]] - CeCED-9 + programmed CED activator
*CED-10
**[[3ajm]] - hCED-10 + inositol tetrakisphosphate<br />
**[[3l8i]], [[3l8j]] - hCED-10<br />
**[[3rqe]], [[3rqf]], [[3rqg]] - hCED-10 + paxillidin peptide<br />
**[[3w8h]], [[3w8i]], [[4geh]] - hCED-10 + serine/threonine kinase regulatory domain<br />
*CED-HAC-1
**[[4v4l]] – CED-HAC-1 – ''Drosophila melanogaster''
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 10:14, 2 July 2020


Cell death proteins or Programmed cell death protein or CD279 (CED) are involved in the process of cellular apoptosis. CED-1 is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. [1] For details on CED-4 see CED-4 Apoptosome. (3bik).[2]. For details on CED-8 see Apoptosis-inducing factor.

Cell death protein 3D structures

Human CED-1 extracellular domain. Programmed cell death protein 1 (green and magenta) and programmed cell death 1 ligand 1 (cyan) complex with glycerol (PDB code 3bik)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Zak KM, Kitel R, Przetocka S, Golik P, Guzik K, Musielak B, Domling A, Dubin G, Holak TA. Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1. Structure. 2015 Oct 22. pii: S0969-2126(15)00402-5. doi:, 10.1016/j.str.2015.09.010. PMID:26602187 doi:http://dx.doi.org/10.1016/j.str.2015.09.010
  2. ↑ Lin DY, Tanaka Y, Iwasaki M, Gittis AG, Su HP, Mikami B, Okazaki T, Honjo T, Minato N, Garboczi DN. The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3011-6. Epub 2008 Feb 14. PMID:18287011

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Michal Harel, Alexander Berchansky
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