Cell death protein: Difference between revisions
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'''Cell death proteins''' or '''Programmed cell death protein''' or '''CD279''' (CED) are involved in the process of cellular apoptosis. '''CED-1''' is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. <ref>PMID:26602187</ref> For details on '''CED-4''' see [[CED-4 Apoptosome]]. <scene name='50/507728/Cv/2'>Programmed cell death protein 1 and programmed cell death 1 ligand 1 complex with glycerol</scene> ([[3bik]]).<ref>PMID:18287011</ref>. For details on '''CED-8''' see [[Apoptosis-inducing factor]]. | '''Cell death proteins''' or '''Programmed cell death protein''' or '''CD279''' (CED) are involved in the process of cellular apoptosis. '''CED-1''' is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. <ref>PMID:26602187</ref> For details on '''CED-4''' see [[CED-4 Apoptosome]]. <scene name='50/507728/Cv/2'>Programmed cell death protein 1 and programmed cell death 1 ligand 1 complex with glycerol</scene> ([[3bik]]).<ref>PMID:18287011</ref>. For details on '''CED-8''' see [[Apoptosis-inducing factor]]. | ||
[[Cell death protein 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
==3D structures of cell death protein== | ==3D structures of cell death protein== | ||
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*CED-1 | *CED-1 | ||
**[[3rrq]] - hCED-1 extracellular domain (mutant) - human<br /> | **[[3rrq]], [[6umu]], [[6umv]] - hCED-1 extracellular domain (mutant) - human<br /> | ||
**[[2m2d]] - hCED-1 extracellular domain - NMR<br /> | **[[2m2d]] - hCED-1 extracellular domain - NMR<br /> | ||
**[[5wt9]], [[5jxe]], [[5b8c]] - hCED-1 extracellular domain + antibody<br /> | **[[5wt9]], [[5jxe]], [[5b8c]] - hCED-1 extracellular domain + antibody<br /> | ||
**[[5ggs]], [[5ggr]] - hCED-1 extracellular domain (mutant) + antibody<br /> | **[[5ggs]], [[5ggr]], [[6hig]], [[6j14]], [[6j15]], [[6jbt]], [[6jjp]], [[6k0y]], [[7bxa]] - hCED-1 extracellular domain (mutant) + antibody<br /> | ||
**[[4zqk]], [[5ius]] - hCED-1 extracellular domain (mutant) + hCED-L1<br /> | |||
**[[6umt]] - hCED-1 extracellular domain (mutant) + hCED-L2 extracellular domain<br /> | |||
**[[1npu]] – mCED-1 extracellular domain (mutant) - mouse<br /> | **[[1npu]] – mCED-1 extracellular domain (mutant) - mouse<br /> | ||
**[[3bik]] - mCED-1 extracellular domain (mutant) + hCED-L1 extracellular domain<br /> | **[[3bik]] - mCED-1 extracellular domain (mutant) + hCED-L1 extracellular domain<br /> | ||