3j0s

Remodeling of actin filaments by ADF cofilin proteinsRemodeling of actin filaments by ADF cofilin proteins

3j0s, resolution 9.00Å Show:Asymmetric Unit Biological Assembly Structural highlights 3j0s is a 24 chain structure with sequence from Gallus gallus and Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: CFL1, CFL (HUMAN) Experimental data: Check Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [ACTB_CHICK] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Publication Abstract from PubMed Cofilin/ADF proteins play key roles in the dynamics of actin, one of the most abundant and highly conserved eukaryotic proteins. We used cryoelectron microscopy to generate a 9-A resolution three-dimensional reconstruction of cofilin-decorated actin filaments, the highest resolution achieved for a complex of F-actin with an actin-binding protein. We show that the cofilin-induced change in the filament twist is due to a unique conformation of the actin molecule unrelated to any previously observed state. The changes between the actin protomer in naked F-actin and in the actin-cofilin filament are greater than the conformational changes between G- and F-actin. Our results show the structural plasticity of actin, suggest that other actin-binding proteins may also induce large but different conformational changes, and show that F-actin cannot be described by a single molecular model. Remodeling of actin filaments by ADF/cofilin proteins.,Galkin VE, Orlova A, Kudryashov DS, Solodukhin A, Reisler E, Schroder GF, Egelman EH Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20568-72. Epub 2011 Dec 7. PMID:22158895 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Actin 3D structures