Transferrin: Difference between revisions

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*<scene name='48/480879/Cv/8'>N-lobe Fe coordination site</scene>.
*<scene name='48/480879/Cv/8'>N-lobe Fe coordination site</scene>.
*<scene name='48/480879/Cv/9'>C-lobe Fe coordination site</scene>.
*<scene name='48/480879/Cv/9'>C-lobe Fe coordination site</scene>.
== 3D Structures of Transferrin ==
[[Transferrin 3D structures]]
</StructureSection>
</StructureSection>
== 3D Structures of Transferrin ==
== 3D Structures of Transferrin ==
Line 19: Line 22:
*Transferrin
*Transferrin


**[[3qyt]], [[3v83]], [[4x1b]] – hTF + Fe+3 - human<br />
**[[3qyt]], [[3v83]], [[4x1b]], [[6jas]], [[6ctc]] – hTF + Fe+3 - human<br />
**[[4x1d]] – hTF + Yb+3 <br />
**[[4x1d]] – hTF + Yb+3 <br />
**[[5dyh]], [[5h52]] – hTF + Ti+4 <br />
**[[5dyh]], [[5h52]] – hTF + Ti+4 <br />
Line 25: Line 28:
**[[5x5p]], [[5wtd]] – hTF + Fe+3 + Ru+3<br />
**[[5x5p]], [[5wtd]] – hTF + Fe+3 + Ru+3<br />
**[[5y6k]] – hTF + Fe+3 + probe<br />
**[[5y6k]] – hTF + Fe+3 + probe<br />
**[[1suv]] – hTF + TF receptor <br />
**[[1suv]], [[6soy]], [[6soz]] – hTF + TF receptor <br />
**[[3s9l]], [[3s9m]], [[3s9n]] - hTF (mutant) + TF receptor<br />
**[[3s9l]], [[3s9m]], [[3s9n]] - hTF (mutant) + TF receptor<br />
**[[1h76]] – TF + Fe+3 - pig<br />
**[[1tfd]] – rTF + Fe+3 - rabbit<br />
**[[6d03]], [[6d04]], [[6d05]] – TF + TF receptor - ''Pasmodium vivax'' - Cryo EM<br />
**[[6d03]], [[6d04]], [[6d05]] – TF + TF receptor - ''Pasmodium vivax'' - Cryo EM<br />


*Transferrin N lobe
*Transferrin N lobe


**[[1tfd]] – rTF N terminal - rabbit<br />
**[[1a8e]], [[1a8f]], [[1b3e]], [[1n84]] - hTF N terminal<br />  
**[[1a8e]], [[1a8f]], [[1b3e]], [[1n84]] - hTF N terminal<br />  
**[[1dtg]], [[1d3k]], [[1d4n]], [[1fqe]], [[1fqf]], [[1jqf]], [[1n7w]], [[1n7x]], [[1oqg]], [[1oqh]], [[2o7u]], [[2o84]], [[3fgs]] - hTF N terminal (mutant)<br />
**[[1dtg]], [[1d3k]], [[1d4n]], [[1fqe]], [[1fqf]], [[1jqf]], [[1n7w]], [[1n7x]], [[1oqg]], [[1oqh]], [[2o7u]], [[2o84]], [[3fgs]] - hTF N terminal (mutant)<br />
**[[1ryo]] - hTF N terminal + oxalate
**[[1ryo]] - hTF N terminal + oxalate
**[[1tfd]] – rTF N terminal <br />


*Transferrin C lobe
*Transferrin C lobe
Line 44: Line 49:
**[[1bp5]], [[1btj]] - hTF N terminal<br />
**[[1bp5]], [[1btj]] - hTF N terminal<br />
**[[2hau]], [[2hav]] – hTF (mutant)<br />
**[[2hau]], [[2hav]] – hTF (mutant)<br />
**[[1jnf]] – rTF <br />
**[[1h76]] – TF - pig


*Ovotransferrin
*Ovotransferrin
Line 61: Line 64:
*Apo ovotransferrin
*Apo ovotransferrin


**[[1lfc]] – OTF residues 17-41 – bovine - NMR<br />
**[[1aov]] – dOTF<br />
**[[1aov]] – dOTF<br />
**[[1aiv]], [[1ryx]]– cOTF<br />
**[[1aiv]], [[1ryx]]– cOTF<br />
**[[1tfa]] - cOTF N terminal<br />
**[[1tfa]] - cOTF N terminal<br />
**[[1iq7]] - cOTF C terminal<br />
**[[1iq7]] - cOTF C terminal<br />
**[[1lfc]] – OTF residues 17-41 – bovine - NMR
 
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:36, 5 March 2020

Function

Transferrin or serotransferrin (TF) is an iron-binding protein. TF delivers iron from absorption centers in the duodendum and white blood cell macrophages to all tissues[1]. Ovotransferrin (OTF) is a glycosylated TF of egg white. For details see Molecular Playground/Transferrin.

Relevance

Carbohydrate-deficient TF may help diagnose alcoholic liver disease[2].

Structural highlights

TF contains : at the N and C termini. The Fe+3 ion is coordinated to several side chains belonging to both N- and C-lobe, carbonate and sulfate ions[3].

  • .
  • .

3D Structures of Transferrin

Transferrin 3D structures


Glycosylated human transferrin with Fe+3 (light red), carbonate and sulfate (PDB code 3qyt).

Drag the structure with the mouse to rotate

3D Structures of Transferrin3D Structures of Transferrin

Updated on 05-March-2020

ReferencesReferences

  1. ↑ de Jong G, van Dijk JP, van Eijk HG. The biology of transferrin. Clin Chim Acta. 1990 Sep;190(1-2):1-46. PMID:2208733
  2. ↑ Liu YS, Xu GY, Cheng DQ, Li YM. Determination of serum carbohydrate-deficient transferrin in the diagnosis of alcoholic liver disease. Hepatobiliary Pancreat Dis Int. 2005 May;4(2):265-8. PMID:15908327
  3. ↑ Yang N, Zhang H, Wang M, Hao Q, Sun H. Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe. Sci Rep. 2012;2:999. doi: 10.1038/srep00999. Epub 2012 Dec 19. PMID:23256035 doi:10.1038/srep00999

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman
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