5cay: Difference between revisions
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==Envelope glycoprotein gp120 core from HIV type 2 bound to the first two domains of human soluble CD4 receptor== | ==Envelope glycoprotein gp120 core from HIV type 2 bound to the first two domains of human soluble CD4 receptor== | ||
<StructureSection load='5cay' size='340' side='right' caption='[[5cay]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='5cay' size='340' side='right'caption='[[5cay]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[5cay]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-2 Hiv-2] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CAY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CAY FirstGlance]. <br> | <table><tr><td colspan='2'>[[5cay]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hiv-2 Hiv-2] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CAY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CAY FirstGlance]. <br> | ||
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==See Also== | ==See Also== | ||
*[[CD4|CD4]] | *[[CD4 3D structures|CD4 3D structures]] | ||
*[[Gp120 3D structures|Gp120 3D structures]] | |||
*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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[[Category: Hiv-2]] | [[Category: Hiv-2]] | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Bjorkman, P J]] | [[Category: Bjorkman, P J]] | ||
[[Category: Davenport, Y W]] | [[Category: Davenport, Y W]] | ||
Revision as of 18:59, 11 December 2019
Envelope glycoprotein gp120 core from HIV type 2 bound to the first two domains of human soluble CD4 receptorEnvelope glycoprotein gp120 core from HIV type 2 bound to the first two domains of human soluble CD4 receptor
Structural highlights
Function[CD4_HUMAN] Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts. Publication Abstract from PubMedHIV-2 is a non-pandemic form of the virus causing AIDS, and the majority of HIV-2-infected patients exhibit long-term non-progression. The HIV-1 and HIV-2 envelope glycoproteins, the sole targets of neutralizing antibodies, share 30-40% identity. As a first step in understanding the reduced pathogenicity of HIV-2, we solved a 3.0 A structure of an HIV-2 gp120 bound to the host receptor CD4, which reveals structural similarity to HIV-1 gp120 despite divergence in amino acid sequence. Structure of an HIV-2 gp120 in complex with CD4.,Davenport YW, West AP Jr, Bjorkman PJ J Virol. 2015 Nov 25. pii: JVI.02678-15. PMID:26608312[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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