1d2q: Difference between revisions
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==CRYSTAL STRUCTURE OF HUMAN TRAIL== | ==CRYSTAL STRUCTURE OF HUMAN TRAIL== | ||
<StructureSection load='1d2q' size='340' side='right' caption='[[1d2q]], [[Resolution|resolution]] 2.80Å' scene=''> | <StructureSection load='1d2q' size='340' side='right'caption='[[1d2q]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1d2q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D2Q FirstGlance]. <br> | <table><tr><td colspan='2'>[[1d2q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1D2Q FirstGlance]. <br> | ||
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</div> | </div> | ||
<div class="pdbe-citations 1d2q" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 1d2q" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[TRAIL|TRAIL]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
[[Category: Large Structures]] | |||
[[Category: Cha, S S]] | [[Category: Cha, S S]] | ||
[[Category: Cytokine]] | [[Category: Cytokine]] | ||
[[Category: Trail]] | [[Category: Trail]] | ||
Revision as of 12:18, 6 November 2019
CRYSTAL STRUCTURE OF HUMAN TRAILCRYSTAL STRUCTURE OF HUMAN TRAIL
Structural highlights
Function[TNF10_HUMAN] Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedTRAIL is a newly identified cytokine belonging to the large tumor necrosis factor (TNF) family. TRAIL is a novel molecule inducing apoptosis in a wide variety of tumor cells but not in normal cells. To help in elucidating its biological roles and designing mutants with improved therapeutic potential, we have determined the crystal structure of human TRAIL. The structure reveals that a unique frame insertion of 12-16 amino acids adopts a salient loop structure penetrating into the receptor-binding site. The loop drastically alters the common receptor-binding surface of the TNF family most likely for the specific recognition of cognate partners. A structure-based mutagenesis study demonstrates a critical role of the insertion loop in the cytotoxic activity of TRAIL. 2.8 A resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity.,Cha SS, Kim MS, Choi YH, Sung BJ, Shin NK, Shin HC, Sung YC, Oh BH Immunity. 1999 Aug;11(2):253-61. PMID:10485660[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences |
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