2lm7: Difference between revisions
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==NMR structure of the C-terminal domain of VP7 in membrane mimicking micelles== | ==NMR structure of the C-terminal domain of VP7 in membrane mimicking micelles== | ||
<StructureSection load='2lm7' size='340' side='right' caption='[[2lm7]], [[NMR_Ensembles_of_Models | 8 NMR models]]' scene=''> | <StructureSection load='2lm7' size='340' side='right'caption='[[2lm7]], [[NMR_Ensembles_of_Models | 8 NMR models]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2lm7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rot41 Rot41]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LM7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2lm7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rot41 Rot41]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LM7 FirstGlance]. <br> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Rot41]] | [[Category: Rot41]] | ||
[[Category: Bouaziz, S]] | [[Category: Bouaziz, S]] | ||
Revision as of 10:07, 6 November 2019
NMR structure of the C-terminal domain of VP7 in membrane mimicking micellesNMR structure of the C-terminal domain of VP7 in membrane mimicking micelles
Structural highlights
Function[VP7_ROT41] Outer capsid protein involved in attachment and possibly entry into the host epithelial cell. It is subsequently lost, together with VP4, following virus entry into the host cell. The outer layer contains 780 copies of VP7, grouped as 260 trimers. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. In integrin-dependent strains, VP7 seems to essentially target the integrin heterodimers ITGAX/ITGB2 and ITGA5/ITGB3 at a postbinding stage, once the initial attachment by VP4 has been achieved (By similarity). |
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