2lm7

NMR structure of the C-terminal domain of VP7 in membrane mimicking micellesNMR structure of the C-terminal domain of VP7 in membrane mimicking micelles

Structural highlights 2lm7 is a 1 chain structure with sequence from Rotavirus A human/BEL/4106/2000 G3P1114. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function VP7_ROT41 Outer capsid protein involved in attachment and possibly entry into the host epithelial cell. It is subsequently lost, together with VP4, following virus entry into the host cell. The outer layer contains 780 copies of VP7, grouped as 260 trimers. Rotavirus attachment and entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. In integrin-dependent strains, VP7 seems to essentially target the integrin heterodimers ITGAX/ITGB2 and ITGA5/ITGB3 at a postbinding stage, once the initial attachment by VP4 has been achieved (By similarity). See Also Virus coat proteins 3D structures

spinqualitylabelsall models 2lm7 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image