6h0s: Difference between revisions

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-'''Unreleased structure'''
-The entry 6h0s is ON HOLD  until Jul 10 2020
+==Crystal structure of the complex between the Lactococcus lactis FPG mutant G226P and a Fapy-dG containing DNA==
+<StructureSection load='6h0s' size='340' side='right'caption='[[6h0s]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
-Authors: Coste, F., Castaing, B., Carell, T.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[6h0s]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6H0S OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6H0S FirstGlance]. <br>
-Description: Crystal structure of the complex between the Lactococcus lactis FPG mutant G226P and a Fapy-dG containing DNA
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=FOX:((1R,2S,4R)-4-{[2-AMINO-5-(FORMYLAMINO)-6-OXO-3,6-DIHYDROPYRIMIDIN-4-YL]AMINO}-2-HYDROXYCYCLOPENTYL)METHYL+5-PHOSPHATE'>FOX</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6h0s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6h0s OCA], [http://pdbe.org/6h0s PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6h0s RCSB], [http://www.ebi.ac.uk/pdbsum/6h0s PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6h0s ProSAT]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/A0A165FVI1_LACLC A0A165FVI1_LACLC]] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.[HAMAP-Rule:MF_00103][SAAS:SAAS00020861]
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Carell, T]]
 [[Category: Castaing, B]]
 [[Category: Coste, F]]
-[[Category: Carell, T]]
+[[Category: Glycosylase]]
+[[Category: Hydantoin lesion]]
+[[Category: Hydrolase]]
+[[Category: Protein-dna complex]]