6h0s

Crystal structure of the complex between the Lactococcus lactis FPG mutant G226P and a Fapy-dG containing DNACrystal structure of the complex between the Lactococcus lactis FPG mutant G226P and a Fapy-dG containing DNA

Structural highlights

6h0s is a 3 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
NonStd Res:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[A0A165FVI1_LACLC] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.[HAMAP-Rule:MF_00103][SAAS:SAAS00020861]

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6h0s

Crystal structure of the complex between the Lactococcus lactis FPG mutant G226P and a Fapy-dG containing DNACrystal structure of the complex between the Lactococcus lactis FPG mutant G226P and a Fapy-dG containing DNA

Structural highlights

Function

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6h0s

Crystal structure of the complex between the Lactococcus lactis FPG mutant G226P and a Fapy-dG containing DNACrystal structure of the complex between the Lactococcus lactis FPG mutant G226P and a Fapy-dG containing DNA

Structural highlights

Function

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